Formulation and process variables influencing nanoparticles properties: Factors influencing properties of nanoparticles prepared by nanoprecipitation and emulsification-based methods - Couverture souple

Simonoska Crcarevska, Maja; Glavas Dodov, Marija; Lazarevski, Nikola

 
9786202077668: Formulation and process variables influencing nanoparticles properties: Factors influencing properties of nanoparticles prepared by nanoprecipitation and emulsification-based methods
Couverture souple
ISBN 10 : 6202077662 ISBN 13 : 9786202077668
Editeur : LAP LAMBERT Academic Publishing, 2017

Synopsis

Having in mind the toxicity of certain drugs, problems associated with multi drug resistance and favorable pharmacokinetic properties offered by nanoparticulated drug delivery systems (NDDS), it could be said that nanoencapsulation is a challengeable and interesting approach to achieve desired benefits of lower toxicity and increased drug accumulation into the target tissue/organ. The first step that needs to be mastered in the NDDS design, is to achieve prolonged blood circulation time by providing the adequate nanoparticle (NP) size (<200 nm), surface charge (preferably neutral), shape and surface properties (preferably hydrophilic) as basic requirements for circumvention of mononuclear phagocyte system and desired NDDS accumulation into the targeted tissue. So, when optimizing NP formulations in order to achieve the desired characteristics in vivo, it is of high importance to consider the various preparation, formulation and process factors that can influence the NP size, zeta potential, encapsulation efficiency and drug dissolution, among other properties. This review gives an overview of most studied factors influencing NDDS physicochemical and biopharmaceutical properties.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Having in mind the toxicity of certain drugs, problems associated with multi drug resistance and favorable pharmacokinetic properties offered by nanoparticulated drug delivery systems (NDDS), it could be said that nanoencapsulation is a challengeable and interesting approach to achieve desired benefits of lower toxicity and increased drug accumulation into the target tissue/organ. The first step that needs to be mastered in the NDDS design, is to achieve prolonged blood circulation time by providing the adequate nanoparticle (NP) size (<200 nm), surface charge (preferably neutral), shape and surface properties (preferably hydrophilic) as basic requirements for circumvention of mononuclear phagocyte system and desired NDDS accumulation into the targeted tissue. So, when optimizing NP formulations in order to achieve the desired characteristics in vivo, it is of high importance to consider the various preparation, formulation and process factors that can influence the NP size, zeta potential, encapsulation efficiency and drug dissolution, among other properties. This review gives an overview of most studied factors influencing NDDS physicochemical and biopharmaceutical properties.

Biographie de l'auteur

Maja Simonoska Crcarevska is ass. prof. at Faculty of pharmacy, Ss. Cyril and Methodius University in Skopje, R. Macedonia. Marija Glavas Dodov is asoc. prof. at the same Faculty. Nikola Lazarevski works in PharmInvent, Czech Republic. Authors have high expertise in the field of design, development & formulation of advanced drug delivery systems.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2017
Langue
anglais
ISBN 10 
6202077662
ISBN 13 
9786202077668
Reliure
Broché
Nombre de pages
120
Coordonnées du fabricant
non disponible
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