Performance capability evaluation of drug-protein binding studies: Pharmacokinetic research in biological fluids - Couverture souple

Wollner, Oliver

9786202205887: Performance capability evaluation of drug-protein binding studies: Pharmacokinetic research in biological fluids

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ISBN 10 : 6202205881 ISBN 13 : 9786202205887

Editeur : AV Akademikerverlag, 2017

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�diteur: AV Akademikerverlag
Date d'�dition: 2017
Langue: anglais
ISBN 10: 6202205881
ISBN 13: 9786202205887
Reliure: Broch�
Nombre de pages: 72
Coordonn�es du fabricant: non disponible
Personne responsable: non disponible

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Performance capability evaluation of drug-protein binding studies

Oliver Wollner

Edit� par AV Akademikerverlag Nov 2017, 2017

ISBN 10 : 6202205881 ISBN 13 : 9786202205887

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The analysis of drug binding by endogenous proteins plays a major role in pharmaceutical drug development. Current binding studies are mainly made with plasma as it is presumed that unbound drugs can move freely between tissues. As this hypothesis has its limits it would be necessary to take the interstitial fluid into account as well. The interstitium is the area where most of the drugs mediate their effect. This fluid, however, is difficult to access due to the narrow space between tissue cells, but modern sampling approaches have shown promising results. It is unclear whether binding essays can also function in fluids with a low-protein content such as the interstitium. In this thesis drug protein binding essays were evaluated with several biological fluids to highlight possible differences in drug binding capacities between tissues. Therefore, several techniques were investigated and compared. Analysis of drug concentrations were performed via LC-MS. 72 pp. Englisch. N� de r�f. du vendeur 9786202205887

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Performance capability evaluation of drug-protein binding studies

Wollner, Oliver

ISBN 10 : 6202205881 ISBN 13 : 9786202205887

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Performance capability evaluation of drug-protein binding studies

Wollner, Oliver

ISBN 10 : 6202205881 ISBN 13 : 9786202205887

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Etat : New. Print on Demand pp. 72. N� de r�f. du vendeur 371011366

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Performance capability evaluation of drug-protein binding studies

Wollner, Oliver

ISBN 10 : 6202205881 ISBN 13 : 9786202205887

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Etat : New. PRINT ON DEMAND pp. 72. N� de r�f. du vendeur 18376082675

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Performance capability evaluation of drug-protein binding studies

Oliver Wollner

Edit� par AV Akademikerverlag, 2017

ISBN 10 : 6202205881 ISBN 13 : 9786202205887

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Wollner OliverOliver Wollner attained his Bachelor degree in Biochemistry at the University of Wuerzburg and wrote his thesis at the Cancer Center at the University Hospital. Then he graduated with a Master of Science degree in Biotec. N� de r�f. du vendeur 385934470

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Performance capability evaluation of drug-protein binding studies

Oliver Wollner

Edit� par AV Akademikerverlag Nov 2017, 2017

ISBN 10 : 6202205881 ISBN 13 : 9786202205887

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The analysis of drug binding by endogenous proteins plays a major role in pharmaceutical drug development. Current binding studies are mainly made with plasma as it is presumed that unbound drugs can move freely between tissues. As this hypothesis has its limits it would be necessary to take the interstitial fluid into account as well. The interstitium is the area where most of the drugs mediate their effect. This fluid, however, is difficult to access due to the narrow space between tissue cells, but modern sampling approaches have shown promising results. It is unclear whether binding essays can also function in fluids with a low-protein content such as the interstitium. In this thesis drug protein binding essays were evaluated with several biological fluids to highlight possible differences in drug binding capacities between tissues. Therefore, several techniques were investigated and compared. Analysis of drug concentrations were performed via LC-MS.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 72 pp. Englisch. N� de r�f. du vendeur 9786202205887

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Performance capability evaluation of drug-protein binding studies : Pharmacokinetic research in biological fluids

Oliver Wollner

Edit� par AV Akademikerverlag

ISBN 10 : 6202205881 ISBN 13 : 9786202205887

Neuf Taschenbuch

impression � la demande

Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The analysis of drug binding by endogenous proteins plays a major role in pharmaceutical drug development. Current binding studies are mainly made with plasma as it is presumed that unbound drugs can move freely between tissues. As this hypothesis has its limits it would be necessary to take the interstitial fluid into account as well. The interstitium is the area where most of the drugs mediate their effect. This fluid, however, is difficult to access due to the narrow space between tissue cells, but modern sampling approaches have shown promising results. It is unclear whether binding essays can also function in fluids with a low-protein content such as the interstitium. In this thesis drug protein binding essays were evaluated with several biological fluids to highlight possible differences in drug binding capacities between tissues. Therefore, several techniques were investigated and compared. Analysis of drug concentrations were performed via LC-MS. N� de r�f. du vendeur 9786202205887

Contacter le vendeur