Controlled Drug Delivery of Hydrophobic Drug: Development and Evaluation of Oral Controlled Drug Delivery of BCS Class-II Drug Glipizide - Couverture souple

Jagtap, Rajesh; Jagtap, Sneha; Chavan, Sandeep

 
9786202518062: Controlled Drug Delivery of Hydrophobic Drug: Development and Evaluation of Oral Controlled Drug Delivery of BCS Class-II Drug Glipizide

Synopsis

Glipizide, an oral hypoglycemic agent, is one of the most commonly prescribed drugs for the treatment of patients with type II diabetes mellitus. It is practically water-insoluble, thus it belongs to class-II of Biopharmaceutical Classification System (BCS). Glipizide has a relatively short elimination half-life (2–4 h), thereby requiring twice daily dosing in large number of patients, which often leads to non-compliance. Thus, there is a strong clinical need and market potential for a dosage form that will deliver glipizide in a controlled manner to a patient needing this therapy, thereby resulting in a better patient compliance. The aim of present investigation was to enhance the solubility by using β-cyclodextrin binary complexation and impart a controlled release in a single formulation in order to reduce dosing frequency.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.