Cancer Immunotherapy: An experimental approach to immunotherapy of cancer using liposomes entrapped tumor associated antigens in mice model - Couverture souple

Longkumer, Imliwati

Couverture souple

ISBN 10 : 6202524537 ISBN 13 : 9786202524537

Editeur : LAP LAMBERT Academic Publishing, 2020

Synopsis

Chemically induced tumors in mice provide a system to investigate tumor-associated antigens (TAA). The cell surface glycoprotein antigens on such tumor cells have been identified as suitable targets for immune attack. The induction of immune responses against TAA in N-nitrosodiethylamine (DEN) has been examined. In order to present antigens to the immune system, the liposome was used as vehicle to deliver the TAA. Liposomal-TAA formulation, elicited both humoral and the cellular immune responses, when administered intramuscularly in DEN-exposed mice. Presence of circulatory antibodies against TAA and the induction of cellular responses in immunized mice were monitored using ELISA and in vitro cell proliferation assay of lymphocytes respectively. Specificity of antibody against TAA in immune sera was analysed using immunoblotting technique. Based on these results, it is proposed that the liposome encapsulated TAA may successfully be used to induce humoral and cellular responses against tumor.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2020
• Langue: anglais
• ISBN 10: 6202524537
• ISBN 13: 9786202524537
• Reliure: Broché
• Nombre de pages: 116
• Coordonnées du fabricant: non disponible
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