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Chemopreventive potential of adrenergic blocker: using prostate cancer induced rats - Couverture souple

Nargatti, Prakash; Patil, Sudhir; Naikwade, Nilofar

 
9786202555050: Chemopreventive potential of adrenergic blocker: using prostate cancer induced rats
Couverture souple
ISBN 10 : 620255505X ISBN 13 : 9786202555050
Editeur : LAP LAMBERT Academic Publishing, 2020

Synopsis

Psychosocial stress increasingly recognized as an important health issue in development and progression of cancer.Prostate cancer patients have increased levels of stress and anxiety. Several studies suggest that environmental factors are important in prostate cancer development. Patients with prostate cancer reportedly show higher levels of anxiety compared with other cancer patients. Based on psychoneuroimmunology we report that stress promotes prostate cancer in rats through stress response system. The sympathetic nervous system potentially regulate tumour α and β-adrenergic signalling both via circulating adrenaline/nor-adrenaline and via local nor-adrenaline release from SNS nerve fibres. Activation of the sympathetic nervous system promotes cancer progression via β-adrenoreceptor–mediated activation of protein kinase A and exchange protein activated by adenylyl cyclase signalling pathways.Stimulation of α¬ receptor leads to the activation of Ca++ permeable nonselective cationic channels and transient receptor potential (TRP) channel family, which are responsible for cell proliferation, which leads to prostate cancer progression.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2020
Langue
anglais
ISBN 10 
620255505X
ISBN 13 
9786202555050
Reliure
Broché
Nombre de pages
116
Coordonnées du fabricant
non disponible
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