Prion proteins, origin, structure, physiological and pathologic roles: Prion proteins roles in humans and animals - Couverture souple

O'Daly, Jose

 
9786202668736: Prion proteins, origin, structure, physiological and pathologic roles: Prion proteins roles in humans and animals
Couverture souple
ISBN 10 : 6202668733 ISBN 13 : 9786202668736
Editeur : LAP LAMBERT Academic Publishing, 2020

Synopsis

Prions are a new concept in medicine and biology. The concepts about α-helix, β-sheet, peptide bond, hydrogen bonds are discussed. Prion diseases cause fatal zoonotic transmissible spongiform encephalopathy, Alzheimer, Huntington and Parkinson diseases in animals and humans. The earliest known Prion disease is Scrapie. Kuru is a fatal neurodegenerative disorder caused by abnormally folded Prion proteins, which leads to symptoms as tremors, loss of coordination. Creutzfeldt–Jakob disease and Gerstmann–Sträussler–Scheinker syndrome are fatal degenerative brain disorders. Fatal familial insomnia results in trouble sleeping. Alzheimer disease causes 60–70% of dementia. Huntington disease is inherited results in the death of brain cells. Prion disease is the transition from α-helix-rich PrPC to rich in β-sheets, responsible for aggregates, and amyloid fibrils. There is no therapeutics to reverse human Prion diseases. Heparin mimetics inhibits Prion propagation in Scrapie infected cells. Other antiprion drugs are tetrapyrroles, branched polyamines, lichens, and β-sheet breaker peptides.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2020
Langue
anglais
ISBN 10 
6202668733
ISBN 13 
9786202668736
Reliure
Broché
Nombre de pages
256
Coordonnées du fabricant
non disponible
Personne responsable
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