Development And Evaluation of Atovaquone Syrup.: By Hydrotropy Method. - Couverture souple

Shimple, Savita; Wadd, Neeta; Tribhuvan, Nitin

Couverture souple

ISBN 10 : 6202670444 ISBN 13 : 9786202670449

Editeur : LAP LAMBERT Academic Publishing, 2020

Synopsis

The Aim of the present research study was to explore the possibility of employing hydrotropy techniques in the formulation and evaluation of aqueous oral liquid formulation of a poorly water soluble drug Atovaquone. In the present study practically insoluble drug Atovaquone was tried to solubilize by employing the combination of physiologically compatible hydrotrope and solubilizer agents i.e. solubilizer to attempt its oral liquid formulations. Hydrotropy is a solubilisation process whereby addition of a large amount of second solute results in an increase in the aqueous solubility of another solute. Hydrotropy method help to improve aqueous solubility of Atovaquone drug having very low aq. Solubility i.e.0.2µg/ml. In this method Atovaquone was solubilized up to 4680.95 mg/ml (increase in solubility).As there is no liquid formulation of Atovaquone available in the market. Atovaquone syrup is useful for the pediatric as well as geriatric to improve patient compliance.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2020
• Langue: anglais
• ISBN 10: 6202670444
• ISBN 13: 9786202670449
• Reliure: Broché
• Nombre de pages: 104
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible