Articles liés à Anti-centromere antibodies in routine use

Anti-centromere antibodies in routine use - Couverture souple

Mejdoub, Sabrina; Cheikh Hamza, Lalla Mariem

 
9786203500295: Anti-centromere antibodies in routine use
Couverture souple
ISBN 10 : 6203500291 ISBN 13 : 9786203500295
Editeur : International Book Market Service Ltd, 2024

Synopsis

Anti-centromere antibodies (ACA) can be detected by indirect immunofluorescence (IFI) or immunodot (ID). Our aim was to assess IFI/ID concordance and the clinical relevance of ACA.Patients presenting with ACA positivity by IFI on Hep-2 cells and/or by ID were included. ACAs were detected in 63 cases (2.1% of IFI+ID tests). ACAs were positive by IFI and ID in 18 cases. Discordances involved 2 cases of ACA-IFI+/ACA-ID- and 43 cases of ACA-IFI-/ACA-ID+. For these 43 cases, the nuclear fluorescence appearance (IFI) was speckled (34), nucleolar speckled (6) or homogeneous (3); ACA (ID) was weakly positive (26), positive (7) or strongly positive (10).The diagnosis of connective tissue disease (systemic scleroderma, systemic lupus erythematosus, rheumatoid arthritis) was retained in 3 patients out of 18 with clinical information. IFI on Hep-2 cells has certain limitations (operator-dependent; one fluorescence appearance may be masked by another). ID is useful for confirming antigenic specificity, within the limits of the antigens used. Interpretation of these tests depends on the clinical context.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
International Book Market Service Ltd
Date d'édition
2024
Langue
anglais
ISBN 10 
6203500291
ISBN 13 
9786203500295
Reliure
Broché
Nombre de pages
52
Coordonnées du fabricant
non disponible
Personne responsable
non disponible