Articles liés à Link Between Dopamine And Protein Changes: Structure...

Link Between Dopamine And Protein Changes: Structure of neurons - Couverture souple

Awada, Fahd

 
9786203526301: Link Between Dopamine And Protein Changes: Structure of neurons
Couverture souple
ISBN 10 : 6203526304 ISBN 13 : 9786203526301
Editeur : Our Knowledge Publishing, 2021

Synopsis

Long-term treatment with dopamine leads to motor complications such as dyskinesia. This indicates that after repeated dopaminergic stimulation, there may be changes in the response of the neuron to the same stimulus. The concept that dopamine transmission can modify the cellular cytoskeleton is novel and not yet well explored. The present study investigates how dopamine transmission is able to influence the cytoskeleton by studying the striatal Tau protein. Our results on the ex vivo side indicate that stimulation of dopamine receptors modifies Tau by altering its phosphorylation via glutamate receptors. On the in vivo side, we demonstrated that dopamine has a tonic effect on Tau phosphorylation and that denervation of dopaminergic neurons is an essential condition to induce changes in the cytoskeleton. This work has allowed us to highlight new molecular mechanisms in dopaminergic transmission during pathological dopaminergic conditions as seen in Parkinson's disease.

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Éditeur
Our Knowledge Publishing
Date d'édition
2021
Langue
anglais
ISBN 10 
6203526304
ISBN 13 
9786203526301
Reliure
Broché
Nombre de pages
72
Coordonnées du fabricant
non disponible
Personne responsable
non disponible