Nadolol Oral Wafers- Formulation and Optimization by Design Expert: ʺDESIGN, FORMULATION AND STATISTICAL OPTIMIZATION OF NADOLOL LOADED ORAL WAFERʺ - Couverture souple
Synopsis
Nadolol is a BCS Class III drug having low permeability and high solubility. It has low oral bioavailability. Formulation of Nadolol into wafers will help in improving the delivery of the drug. The design of the formulation started with the factorial design to optimize the independent variables like the amount of PEG, SLS and SSA. Formulation batches of wafers were prepared in accordance with Box BehnKen Design and evaluation tests were performed. It was observed that the independent parameters concentration of PEG, SLS and SSA show impact on disintegration time, folding endurance and thickness of the wafers. The data obtained in the factorial experiments was used for plotting response-surface and contour plots and data was analyzed by ANOVA. Optimized formulae were given by the software. The optimized formulations were prepared and evaluated. The formulation having the lowest % relative error of the predicted values given by the software and the experimental values was considered the best. OF1 was found to show better results. The optimized formulation of nadolol loaded wafers was then subjected to in vitro drug release studies.
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Nadolol Oral Wafers- Formulation and Optimization by Design Expert
Edité par
LAP LAMBERT Academic Publishing Sep 2021, 2021
ISBN 10 : 6204203401
ISBN 13 : 9786204203409
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Nadolol is a BCS Class III drug having low permeability and high solubility. It has low oral bioavailability. Formulation of Nadolol into wafers will help in improving the delivery of the drug. The design of the formulation started with the factorial design to optimize the independent variables like the amount of PEG, SLS and SSA. Formulation batches of wafers were prepared in accordance with Box BehnKen Design and evaluation tests were performed. It was observed that the independent parameters concentration of PEG, SLS and SSA show impact on disintegration time, folding endurance and thickness of the wafers. The data obtained in the factorial experiments was used for plotting response-surface and contour plots and data was analyzed by ANOVA. Optimized formulae were given by the software. The optimized formulations were prepared and evaluated. The formulation having the lowest % relative error of the predicted values given by the software and the experimental values was considered the best. OF1 was found to show better results. The optimized formulation of nadolol loaded wafers was then subjected to in vitro drug release studies. 84 pp. Englisch. N° de réf. du vendeur 9786204203409
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Nadolol Oral Wafers- Formulation and Optimization by Design Expert
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204203401
ISBN 13 : 9786204203409
Neuf
Couverture souple
Vendeur : moluna, Greven, Allemagne
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: AVASARALA HARANIDr. Harani Avasarala working as an Associate Professor at Aditya College of Pharmacy, India, received her Ph.D. from Andhra University availing prestigious DST INSPIRE fellowship. She was Osmania University Topper in . N° de réf. du vendeur 516610405
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Nadolol Oral Wafers- Formulation and Optimization by Design Expert
Edité par
LAP LAMBERT Academic Publishing Sep 2021, 2021
ISBN 10 : 6204203401
ISBN 13 : 9786204203409
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Nadolol is a BCS Class III drug having low permeability and high solubility. It has low oral bioavailability. Formulation of Nadolol into wafers will help in improving the delivery of the drug. The design of the formulation started with the factorial design to optimize the independent variables like the amount of PEG, SLS and SSA. Formulation batches of wafers were prepared in accordance with Box BehnKen Design and evaluation tests were performed. It was observed that the independent parameters concentration of PEG, SLS and SSA show impact on disintegration time, folding endurance and thickness of the wafers. The data obtained in the factorial experiments was used for plotting response-surface and contour plots and data was analyzed by ANOVA. Optimized formulae were given by the software. The optimized formulations were prepared and evaluated. The formulation having the lowest % relative error of the predicted values given by the software and the experimental values was considered the best. OF1 was found to show better results. The optimized formulation of nadolol loaded wafers was then subjected to in vitro drug release studies.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 84 pp. Englisch. N° de réf. du vendeur 9786204203409
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Nadolol Oral Wafers- Formulation and Optimization by Design Expert : ¿DESIGN, FORMULATION AND STATISTICAL OPTIMIZATION OF NADOLOL LOADED ORAL WAFER¿
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204203401
ISBN 13 : 9786204203409
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Nadolol is a BCS Class III drug having low permeability and high solubility. It has low oral bioavailability. Formulation of Nadolol into wafers will help in improving the delivery of the drug. The design of the formulation started with the factorial design to optimize the independent variables like the amount of PEG, SLS and SSA. Formulation batches of wafers were prepared in accordance with Box BehnKen Design and evaluation tests were performed. It was observed that the independent parameters concentration of PEG, SLS and SSA show impact on disintegration time, folding endurance and thickness of the wafers. The data obtained in the factorial experiments was used for plotting response-surface and contour plots and data was analyzed by ANOVA. Optimized formulae were given by the software. The optimized formulations were prepared and evaluated. The formulation having the lowest % relative error of the predicted values given by the software and the experimental values was considered the best. OF1 was found to show better results. The optimized formulation of nadolol loaded wafers was then subjected to in vitro drug release studies. N° de réf. du vendeur 9786204203409
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Nadolol Oral Wafers- Formulation and Optimization by Design Expert | ¿DESIGN, FORMULATION AND STATISTICAL OPTIMIZATION OF NADOLOL LOADED ORAL WAFER¿
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204203401
ISBN 13 : 9786204203409
Neuf
Taschenbuch
Vendeur : preigu, Osnabrück, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. Nadolol Oral Wafers- Formulation and Optimization by Design Expert | ¿DESIGN, FORMULATION AND STATISTICAL OPTIMIZATION OF NADOLOL LOADED ORAL WAFER¿ | Harani Avasarala (u. a.) | Taschenbuch | Englisch | 2021 | LAP LAMBERT Academic Publishing | EAN 9786204203409 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 120687443
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