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Synopsis
The objective of the present study was to develop an optimized gastroretentive floating drug delivery system of Olmesartan Medoxomil and investigate the effect of hydrophilic retardant on invitro release by using 32 full factorial design. Floating tablets of olmesartan medoxomil were prepared by direct compression method using effervescent technique by employing two different grades of HPMC. (HPMC K4M and HPMC K100M). Sodium bicarbonate was incorporated as gas generating agent. The concentration of HPMC K4M (X1) and concentration of HPMC K100M (X2) were selected as independent variables.The floating lag time, total floating time and time taken to 80 % drug release were selected as dependent variables. Targets were defined for each response so as to select the optimim formula using numerical optimization. All the floating matrix tablets formulations were subjected to pre-compression and post-compression parameter evaluation.
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Gastroretentive Floating Drug Delivery System of Olmesartan Medoxomil
Edité par
LAP LAMBERT Academic Publishing Sep 2021, 2021
ISBN 10 : 6204203959
ISBN 13 : 9786204203959
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The objective of the present study was to develop an optimized gastroretentive floating drug delivery system of Olmesartan Medoxomil and investigate the effect of hydrophilic retardant on invitro release by using 32 full factorial design. Floating tablets of olmesartan medoxomil were prepared by direct compression method using effervescent technique by employing two different grades of HPMC. (HPMC K4M and HPMC K100M). Sodium bicarbonate was incorporated as gas generating agent. The concentration of HPMC K4M (X1) and concentration of HPMC K100M (X2) were selected as independent variables.The floating lag time, total floating time and time taken to 80 % drug release were selected as dependent variables. Targets were defined for each response so as to select the optimim formula using numerical optimization. All the floating matrix tablets formulations were subjected to pre-compression and post-compression parameter evaluation. 128 pp. Englisch. N° de réf. du vendeur 9786204203959
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Gastroretentive Floating Drug Delivery System of Olmesartan Medoxomil
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204203959
ISBN 13 : 9786204203959
Neuf
Couverture souple
Vendeur : moluna, Greven, Allemagne
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Sharma AnjaliAnjali Sharma is presently working as Assistant Professor at Guru Gobind Singh College of Pharmacy. Her field of specialization is Pharmaceutics. She has 7 plus years of teaching experience.Devkant Sharma is presently wo. N° de réf. du vendeur 521055318
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Gastroretentive Floating Drug Delivery System of Olmesartan Medoxomil
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204203959
ISBN 13 : 9786204203959
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The objective of the present study was to develop an optimized gastroretentive floating drug delivery system of Olmesartan Medoxomil and investigate the effect of hydrophilic retardant on invitro release by using 32 full factorial design. Floating tablets of olmesartan medoxomil were prepared by direct compression method using effervescent technique by employing two different grades of HPMC. (HPMC K4M and HPMC K100M). Sodium bicarbonate was incorporated as gas generating agent. The concentration of HPMC K4M (X1) and concentration of HPMC K100M (X2) were selected as independent variables.The floating lag time, total floating time and time taken to 80 % drug release were selected as dependent variables. Targets were defined for each response so as to select the optimim formula using numerical optimization. All the floating matrix tablets formulations were subjected to pre-compression and post-compression parameter evaluation. N° de réf. du vendeur 9786204203959
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Gastroretentive Floating Drug Delivery System of Olmesartan Medoxomil
Edité par
LAP LAMBERT Academic Publishing Sep 2021, 2021
ISBN 10 : 6204203959
ISBN 13 : 9786204203959
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The objective of the present study was to develop an optimized gastroretentive floating drug delivery system of Olmesartan Medoxomil and investigate the effect of hydrophilic retardant on invitro release by using 32 full factorial design. Floating tablets of olmesartan medoxomil were prepared by direct compression method using effervescent technique by employing two different grades of HPMC. (HPMC K4M and HPMC K100M). Sodium bicarbonate was incorporated as gas generating agent. The concentration of HPMC K4M (X1) and concentration of HPMC K100M (X2) were selected as independent variables.The floating lag time, total floating time and time taken to 80 % drug release were selected as dependent variables. Targets were defined for each response so as to select the optimim formula using numerical optimization. All the floating matrix tablets formulations were subjected to pre-compression and post-compression parameter evaluation.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 128 pp. Englisch. N° de réf. du vendeur 9786204203959
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Gastroretentive Floating Drug Delivery System of Olmesartan Medoxomil
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204203959
ISBN 13 : 9786204203959
Neuf
Taschenbuch
Vendeur : preigu, Osnabrück, Allemagne
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Taschenbuch. Etat : Neu. Gastroretentive Floating Drug Delivery System of Olmesartan Medoxomil | Anjali Sharma (u. a.) | Taschenbuch | Englisch | 2021 | LAP LAMBERT Academic Publishing | EAN 9786204203959 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 120730234
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