Synopsis
Nalidixic acid-Tryptophan conjugate was synthesized by coupling Nalidixic acid with glycine methyl ester hydrochloride and characterized by melting point, thin layer chromatography, RM value, scanning electron microscopy, x-ray diffraction study and high performance liquid chromatography. The structure of prodrug was confirmed by analytical techniques, elemental analysis, fourier transform infrared spectroscopy, fourier transform nuclear magnetic resonance spectroscopy and mass spectroscopy. Preformulation studies revealed increased aqueous solubility with non significant change in lipophilicity of Nalidixic acid-Tryptophan conjugate than Nalidixic acid. In vitro reversion confirmed that the prodrug reversion was non significant in gastric environment, thus the objective of bypassing the GIT without any free drug release was achieved. However 67.83 % reversion of Nalidixic acid-Tryptophan conjugate to Nalidixic acid was observed in phosphate buffer pH 6.8 in presence of 20% w/v fresh rat fecal matter due to hydrolysis of amide linkage by amidase enzyme secreted by colonic microflora.
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Colon Targeted Prodrug Approach
Edité par
LAP LAMBERT Academic Publishing Sep 2021, 2021
ISBN 10 : 6204206680
ISBN 13 : 9786204206684
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Nalidixic acid-Tryptophan conjugate was synthesized by coupling Nalidixic acid with glycine methyl ester hydrochloride and characterized by melting point, thin layer chromatography, RM value, scanning electron microscopy, x-ray diffraction study and high performance liquid chromatography. The structure of prodrug was confirmed by analytical techniques, elemental analysis, fourier transform infrared spectroscopy, fourier transform nuclear magnetic resonance spectroscopy and mass spectroscopy. Preformulation studies revealed increased aqueous solubility with non significant change in lipophilicity of Nalidixic acid-Tryptophan conjugate than Nalidixic acid. In vitro reversion confirmed that the prodrug reversion was non significant in gastric environment, thus the objective of bypassing the GIT without any free drug release was achieved. However 67.83 % reversion of Nalidixic acid-Tryptophan conjugate to Nalidixic acid was observed in phosphate buffer pH 6.8 in presence of 20% w/v fresh rat fecal matter due to hydrolysis of amide linkage by amidase enzyme secreted by colonic microflora. 84 pp. Englisch. N° de réf. du vendeur 9786204206684
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Colon Targeted Prodrug Approach
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204206680
ISBN 13 : 9786204206684
Neuf
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Vendeur : moluna, Greven, Allemagne
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Kartoniert / Broschiert. Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Singh Mahendra KumarDr. Mahendra Kumar Singh is working as Assistant Professor in Government Pharmacy College, BRD Medical College Gorakhpur. He has several international patents and research publications in SCOPUS and SCI indexed jo. N° de réf. du vendeur 521055323
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Colon Targeted Prodrug Approach
Edité par
LAP LAMBERT Academic Publishing Sep 2021, 2021
ISBN 10 : 6204206680
ISBN 13 : 9786204206684
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Nalidixic acid-Tryptophan conjugate was synthesized by coupling Nalidixic acid with glycine methyl ester hydrochloride and characterized by melting point, thin layer chromatography, RM value, scanning electron microscopy, x-ray diffraction study and high performance liquid chromatography. The structure of prodrug was confirmed by analytical techniques, elemental analysis, fourier transform infrared spectroscopy, fourier transform nuclear magnetic resonance spectroscopy and mass spectroscopy. Preformulation studies revealed increased aqueous solubility with non significant change in lipophilicity of Nalidixic acid-Tryptophan conjugate than Nalidixic acid. In vitro reversion confirmed that the prodrug reversion was non significant in gastric environment, thus the objective of bypassing the GIT without any free drug release was achieved. However 67.83 % reversion of Nalidixic acid-Tryptophan conjugate to Nalidixic acid was observed in phosphate buffer pH 6.8 in presence of 20% w/v fresh rat fecal matter due to hydrolysis of amide linkage by amidase enzyme secreted by colonic microflora.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 84 pp. Englisch. N° de réf. du vendeur 9786204206684
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Colon Targeted Prodrug Approach : Colon Targeted
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204206680
ISBN 13 : 9786204206684
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Nalidixic acid-Tryptophan conjugate was synthesized by coupling Nalidixic acid with glycine methyl ester hydrochloride and characterized by melting point, thin layer chromatography, RM value, scanning electron microscopy, x-ray diffraction study and high performance liquid chromatography. The structure of prodrug was confirmed by analytical techniques, elemental analysis, fourier transform infrared spectroscopy, fourier transform nuclear magnetic resonance spectroscopy and mass spectroscopy. Preformulation studies revealed increased aqueous solubility with non significant change in lipophilicity of Nalidixic acid-Tryptophan conjugate than Nalidixic acid. In vitro reversion confirmed that the prodrug reversion was non significant in gastric environment, thus the objective of bypassing the GIT without any free drug release was achieved. However 67.83 % reversion of Nalidixic acid-Tryptophan conjugate to Nalidixic acid was observed in phosphate buffer pH 6.8 in presence of 20% w/v fresh rat fecal matter due to hydrolysis of amide linkage by amidase enzyme secreted by colonic microflora. N° de réf. du vendeur 9786204206684
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Colon Targeted Prodrug Approach | Colon Targeted
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204206680
ISBN 13 : 9786204206684
Neuf
Taschenbuch
Vendeur : preigu, Osnabrück, Allemagne
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Taschenbuch. Etat : Neu. Colon Targeted Prodrug Approach | Colon Targeted | Mahendra Kumar Singh (u. a.) | Taschenbuch | Englisch | 2021 | LAP LAMBERT Academic Publishing | EAN 9786204206684 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 120730239
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Colon Targeted Prodrug Approach: Colon Targeted
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204206680
ISBN 13 : 9786204206684
Neuf
paperback
Vendeur : Mispah books, Redhill, SURRE, Royaume-Uni
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paperback. Etat : New. NEW. SHIPS FROM MULTIPLE LOCATIONS. book. N° de réf. du vendeur ERICA82962042066806
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