Development of Mucoadhesive Buccal Patch of Timolol Maleate - Couverture souple

Solanki, Dharmendra; Patidar, Madhuri

 
9786204211381: Development of Mucoadhesive Buccal Patch of Timolol Maleate
Couverture souple
ISBN 10 : 6204211382 ISBN 13 : 9786204211381
Editeur : LAP LAMBERT Academic Publishing, 2021

Synopsis

The present study includes the Formulation and Evaluation of Mucoadhesive Buccal Patch of Timolol Maleate for this study work timolol maleate selected as model drug and using either ionic polymers (SCMC) or non-ionic polymers (carbopol, HPMC).The fabricated patches were prepared by solvent casting method. The mean thicknesses of the buccal patch formulations were 0.34 – 0.43 mm.Moisture uptake of transdermal patches were found to be 2.94-4.13.which prevents the patches from microbial growth and bulkiness. As amount of PVP increased in every polymer blend, tensile strength and elongation at break were increased. Addition of PVP predominantly decreased the swelling characteristics of the buccal patches, except for SCMC. The drug content of the prepared bioadhesive buccal patches were found in the range of 91.4 - 98.54 %.Bioadhesive strength of buccal patches in following order SCMC >Carbopol>HPMC. The release of Timolol maleate from HPMC patches was slower than SCMC and CP 934.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2021
Langue
anglais
ISBN 10 
6204211382
ISBN 13 
9786204211381
Reliure
Broché
Nombre de pages
132
Coordonnées du fabricant
non disponible
Personne responsable
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