Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors: Design, Synthesis, QSAR studies and Biological evaluation of Novel Triazolopiperazine Based DPP-IV Inhibitors - Couverture souple
Synopsis
Diabetes mellitus (DM) is one of the most common chronic disorder with increasing prevalence worldwide. Different classes of oral anti-hyperglycemic agents with nearly equipotent efficacy are now available; however, almost all of them are associated with one or more adverse effects. The new approaches in management of type 2 DM (T2DM) are based upon the effects of incretin hormones; Glucagon-Like Peptide-1 (GLP-1), Glucose-dependent insulinotropic peptide (GIP) and dipeptidyl peptidase (DPP-IV) inhibitors, which act via enhancing the incretin secretion. QSAR is the computer-based mathematical model which establishes a correlation between structure and its biological activity. In present studies, QSAR of one of the reported triazolopiperazine based β-aminoamides have been studied. In present studies, an attempt was made to synthesize the novel and selective 3-amino-1-(8- (cyclopropyl(3-mercapto-4H-1,2,4-triazol-4-ylamino)methyl)-2-(trifluoromtrifluromethyl)-5,6,7,8-tetrahydro-imidazolo(4,5a)-piperidine.The details of the regressional analysis, QSAR, rationale behind design, synthesis, structural characterisation and DPP- IV enzyme inhibitory activity are presented.
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Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors
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LAP LAMBERT Academic Publishing Okt 2021, 2021
ISBN 10 : 6204211420
ISBN 13 : 9786204211428
Neuf
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Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Diabetes mellitus (DM) is one of the most common chronic disorder with increasing prevalence worldwide. Different classes of oral anti-hyperglycemic agents with nearly equipotent efficacy are now available; however, almost all of them are associated with one or more adverse effects. The new approaches in management of type 2 DM (T2DM) are based upon the effects of incretin hormones; Glucagon-Like Peptide-1 (GLP-1), Glucose-dependent insulinotropic peptide (GIP) and dipeptidyl peptidase (DPP-IV) inhibitors, which act via enhancing the incretin secretion. QSAR is the computer-based mathematical model which establishes a correlation between structure and its biological activity. In present studies, QSAR of one of the reported triazolopiperazine based beta-aminoamides have been studied. In present studies, an attempt was made to synthesize the novel and selective 3-amino-1-(8- (cyclopropyl(3-mercapto-4H-1,2,4-triazol-4-ylamino)methyl)-2-(tri fluoromtrifluromethyl)-5,6,7,8-tetrahydro-imidazolo(4,5a)-pi peridine.The details of the regressional analysis, QSAR, rationale behind design, synthesis, structural characterisation and DPP- IV enzyme inhibitory activity are presented. 120 pp. Englisch. N° de réf. du vendeur 9786204211428
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Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors
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LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204211420
ISBN 13 : 9786204211428
Neuf
Couverture souple
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Dhane KetakiMrs. Ketaki S. Dhane Asst. Prof in Department of Pharmaceutical Chemistry at Indira Institute of pharmacy Sadavali affiliated to Mumbai University, Done B. Pharm from Shivaji University and M. Pharm from Savitribai Phule. N° de réf. du vendeur 527327214
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Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors
Edité par
LAP LAMBERT Academic Publishing Okt 2021, 2021
ISBN 10 : 6204211420
ISBN 13 : 9786204211428
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Diabetes mellitus (DM) is one of the most common chronic disorder with increasing prevalence worldwide. Different classes of oral anti-hyperglycemic agents with nearly equipotent efficacy are now available; however, almost all of them are associated with one or more adverse effects. The new approaches in management of type 2 DM (T2DM) are based upon the effects of incretin hormones; Glucagon-Like Peptide-1 (GLP-1), Glucose-dependent insulinotropic peptide (GIP) and dipeptidyl peptidase (DPP-IV) inhibitors, which act via enhancing the incretin secretion. QSAR is the computer-based mathematical model which establishes a correlation between structure and its biological activity. In present studies, QSAR of one of the reported triazolopiperazine based ß-aminoamides have been studied. In present studies, an attempt was made to synthesize the novel and selective 3-amino-1-(8- (cyclopropyl(3-mercapto-4H-1,2,4-triazol-4-ylamino)methyl)-2-(trifluorom trifluromethyl)-5,6,7,8-tetrahydro-imidazolo(4,5a)-piperidin e.The details of the regressional analysis, QSAR, rationale behind design, synthesis, structural characterisation and DPP- IV enzyme inhibitory activity are presented.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 120 pp. Englisch. N° de réf. du vendeur 9786204211428
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Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors : Design, Synthesis, QSAR studies and Biological evaluation of Novel Triazolopiperazine Based DPP-IV Inhibitors
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204211420
ISBN 13 : 9786204211428
Neuf
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Diabetes mellitus (DM) is one of the most common chronic disorder with increasing prevalence worldwide. Different classes of oral anti-hyperglycemic agents with nearly equipotent efficacy are now available; however, almost all of them are associated with one or more adverse effects. The new approaches in management of type 2 DM (T2DM) are based upon the effects of incretin hormones; Glucagon-Like Peptide-1 (GLP-1), Glucose-dependent insulinotropic peptide (GIP) and dipeptidyl peptidase (DPP-IV) inhibitors, which act via enhancing the incretin secretion. QSAR is the computer-based mathematical model which establishes a correlation between structure and its biological activity. In present studies, QSAR of one of the reported triazolopiperazine based beta-aminoamides have been studied. In present studies, an attempt was made to synthesize the novel and selective 3-amino-1-(8- (cyclopropyl(3-mercapto-4H-1,2,4-triazol-4-ylamino)methyl)-2-(trifluor omtrifluromethyl)-5,6,7,8-tetrahydro-imidazolo(4,5a)-piperid ine.The details of the regressional analysis, QSAR, rationale behind design, synthesis, structural characterisation and DPP- IV enzyme inhibitory activity are presented. N° de réf. du vendeur 9786204211428
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Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors | Design, Synthesis, QSAR studies and Biological evaluation of Novel Triazolopiperazine Based DPP-IV Inhibitors
Edité par
LAP LAMBERT Academic Publishing, 2021
ISBN 10 : 6204211420
ISBN 13 : 9786204211428
Neuf
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Vendeur : preigu, Osnabrück, Allemagne
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Taschenbuch. Etat : Neu. Design, Synthesis, QSAR Studies of some DPP-IV Inhibitors | Design, Synthesis, QSAR studies and Biological evaluation of Novel Triazolopiperazine Based DPP-IV Inhibitors | Ketaki Dhane | Taschenbuch | Englisch | 2021 | LAP LAMBERT Academic Publishing | EAN 9786204211428 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 120806187
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