Enhancing the solubility by drug by lipid based delivery systems - Couverture souple

Mounika, Nandru; Nadendla, Ramarao; Ramireddy, G. Venkata

Couverture souple

ISBN 10 : 6204984926 ISBN 13 : 9786204984926

Editeur : LAP LAMBERT Academic Publishing, 2022

Synopsis

The formulation of drugs is carried out with the principle objective of enhancing their bioavailability. Poorly water soluble drugs are challenging for the formulation scientists with regard to solubility and bioavailability. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address such challenges. Lipid-based delivery systems are becoming increasingly popular as carriers of drugs due to their ability to overcome barriers to oral absorption. The objective of the present study was to prepare novel lipid-based formulation of a sparingly soluble drug, Ciprofloxacin hydrochloride (CLX) to increase its saturation solubility and dissolution velocity for enhancing bioavailability while reducing systemic variability. Lipid-based formulations were prepared using melt solubilization technique. The liquid formulations were converted into a solid intermediate by adsorbing onto an inert carrier and blended with excipients for encapsulation. The solid state properties, surface morphology and in-vitro release characteristics of the lipid formulations were investigated and compared with commercial formulation.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2022
• Langue: anglais
• ISBN 10: 6204984926
• ISBN 13: 9786204984926
• Reliure: Broché
• Nombre de pages: 120
• Coordonnées du fabricant: non disponible
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