Optimization of Nanoparticles composed Pyridostigmine: Preparation, Evaluation & Optimization - Couverture souple

Kumar, Niwash; Singh, Nitish Kumar

Couverture souple

ISBN 10 : 6205517426 ISBN 13 : 9786205517420

Editeur : LAP LAMBERT Academic Publishing, 2022

Synopsis

The purpose of this book will to prepare Pyridostigmine nanoparticles for control release of Pyridostigmine to improve the oral bioavailability, enhance the solubility and dissolution rate by decreasing particle size of drug. Infrared spectroscopic studies confirmed that there was no interaction between drug and polymers. The controlled release Pyridostigmine nanoparticles were prepared by Solvent evaporation by using Ethyl cellulose, Chitosan & HPMC K100 at different ratios. The production yield of the formulated controlled release nanoparticles (F1 to F16) in the range of 76.11 % to 83.58 %. The drug content of the formulated controlled release nanoparticles (F1 to F16) in the range of 82.56 %to 98.20%. The Theoretical loading of the formulated controlled release nanoparticles (F1- F16) in the range of 24.43 % to 64.24%. The entrapment efficiency increased with increasing the concentration of polymers and the formulations containing chitosan nanoparticles F6 (1:2) showed better entrapment (90.94%) among all formulation.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2022
• Langue: anglais
• ISBN 10: 6205517426
• ISBN 13: 9786205517420
• Reliure: Broché
• Nombre de pages: 92
• Coordonnées du fabricant: non disponible
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