Evaluation of Retinopathic Effect of Gatifloxacin in Rabbits: Effect of Gatifloxacin on Retina of Rabbits: Role of Tissue Oxidative Stress - Couverture souple

Kumbhar, Ganesh Bhagvan; Rampal, Satyavan; Khan, Adil Mehraj

Couverture souple

ISBN 10 : 6205519887 ISBN 13 : 9786205519882

Editeur : LAP LAMBERT Academic Publishing, 2022

Synopsis

The present investigation reports the effect of repeated administration of gatifloxacin on the antioxidant status and its potential to induce retinal damage in rabbits. Prolonged exposure to gatifloxacin resulted in marked alteration in antioxidant status. There was a significant increase in extent of lipid peroxidation. The activity of antioxidant enzymes viz. glutathione peroxidise and catalase was significantly increased, whereas there was a significant decrease in superoxide dismutase activity. The blood glutathione level was reduced. Similar alterations in antioxidant status were observed in different organs. The histopathological examination of tunics of eyeball revealed clumping of nuclei of outer nuclear layer of rabbits receiving higher dose. The histopathological examination of tunics of eyeball revealed clumping of nuclei of outer nuclear layer of rabbits receiving higher dose. The histopathology of liver and kidney revealed degenerative changes. There was cholangiohepatitis alongwith mononuclear cells infiltration. There was mild degeneration of renal tubular epithelial cells.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2022
• Langue: anglais
• ISBN 10: 6205519887
• ISBN 13: 9786205519882
• Reliure: Broché
• Nombre de pages: 100
• Coordonnées du fabricant: non disponible
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