ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION: SELF-EMULSIFIED DRUG DELIVERY SYSTEM - Couverture souple

Biswal, Prasanta Kumar; SAHU, PRAFULLA KUMAR

 
9786205528082: ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION: SELF-EMULSIFIED DRUG DELIVERY SYSTEM
Couverture souple
ISBN 10 : 6205528088 ISBN 13 : 9786205528082
Editeur : LAP LAMBERT Academic Publishing, 2022

Synopsis

Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30–60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2022
Langue
anglais
ISBN 10 
6205528088
ISBN 13 
9786205528082
Reliure
Broché
Nombre de pages
76
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne