Diclofenac Potassium Tablet for Colon Targeting: Formulation: Diclofenac Potassium Tablet for Colon Targeting - Couverture souple

Shinde, Anilkumar; Jarag, Ravindra; More, Harinath

Couverture souple

ISBN 10 : 6206181219 ISBN 13 : 9786206181217

Editeur : LAP LAMBERT Academic Publishing, 2023

Synopsis

The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Ethyl Cellulose(N22), Cross Povidone and Sodium Starch Glycolate as a superdisintegrants and Instacoat EN super II as a enteric coat to the colone specific tablet. A 33 randomized full factorial design, 3 level and 3 factors were used. The concentration of Hydroxy propyl cellulose (X1), concentration of HPMC K4M (X2) and concentration of Ethyl cellulose (X3) were selected as independent variables. The percentage drug release at 12 hours (Q12), percentage friability and hardness of tablet were selected as dependent variables for optimization study. The core, press coat tablets were compressed by rotatory tablet machine evaluated with different parameters like diameter, thickness, average weight, hardness, friability, kinetic release data. Hardness of tablets was found to be in the range of 7–8 kg/cm2. The enteric coated tablets containing diclofenac potassium released 38.12 % at the end of 12 hrs by in vitro release study.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2023
• Langue: anglais
• ISBN 10: 6206181219
• ISBN 13: 9786206181217
• Reliure: Broché
• Nombre de pages: 52
• Coordonnées du fabricant: non disponible
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