DEVELOPMENT OF FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING: FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING - Couverture souple

Shinde, Anilkumar; Gaikwad, Dinanath; More, Harinath

Couverture souple

ISBN 10 : 620673949X ISBN 13 : 9786206739494

Editeur : LAP LAMBERT Academic Publishing, 2025

Synopsis

Objective: The objective of the present investigation was to development of enteric coated tablet of fenoprofen calcium. Methods: The 32factorial design was used to preparation of compression‐coated with a mixture of time dependent hydrophilic swellable polymer hydropropylcellulose (HPC), time released polymer Ethyl cellulose (EC) and pH responsive soluble polymer Instacoat EN Super II. The developed formulations were characterized for angle of repose, density, carr’s index of powder mixture and thickness, diameter, hardness, friability, weight variation, uniformity content, in vitro disintegration, dissolution study. Results: The results showed that disintegration time and dissolution study of inner core tablet found to be in the range of 7.15 to 13.34 min and 95.92±0.011% at 30 min. The press coat tablets at optimum concentrations of hydroxy propyl cellulose (200 mg) and ethyl cellulose N-22 (200 mg) showed the % drug release 83.53±0.014% at 12 hr. % cumulative drug release of enteric coated tablet of optimized batch FT9 showed 76.08±0.045 at 12h, it indicated that drug release at sustained manner.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2025
• Langue: anglais
• ISBN 10: 620673949X
• ISBN 13: 9786206739494
• Reliure: Broché
• Nombre de pages: 56
• Coordonnées du fabricant: non disponible
• Personne responsable: KreGa Onlinehandel GmbH; 4950000000000; info@krega-onlinehandel.de; ; Birkenweg 31; Brakel; 33034; Allemagne