Alternative Laboratory Models for Drug Discovery: Zebra Fish - Couverture souple

Narkhede, Mahesh; Chinchole, Pavan

 
9786206770008: Alternative Laboratory Models for Drug Discovery: Zebra Fish
Couverture souple
ISBN 10 : 6206770001 ISBN 13 : 9786206770008
Editeur : Scholars' Press, 2023

Synopsis

Embryonic and larval Danio rerio (zebrafish) is increasingly used as a toxicological model to conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features high genetic homology to mammals, robust, phenotypes, high-throughput genetic and chemical screening have made it a powerful tool to evaluate in vivo toxicity. New methodologies of genome editing as CRISPR/Cas9; ZFN and TALEN make it a suitable model to perform studies to pair human genetic diseases as well. This review surveys recent studies employing zebrafish as experimental model, comparing it with other in vivo and in vitro models, presenting zebrafish as a potent vertebrate tool to evaluate drug toxicity and efficacy in order to facilitate more extensive, easy and comprehensive knowledge of new generation drugs.

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Éditeur
Scholars' Press
Date d'édition
2023
Langue
anglais
ISBN 10 
6206770001
ISBN 13 
9786206770008
Reliure
Broché
Nombre de pages
56
Coordonnées du fabricant
non disponible
Personne responsable
non disponible