The Unfolded Protein Response Pathway and Lung Cancer: Intervention by phytochemicals - Couverture souple

Chatterjee, Bhaskar; Ghosh, Swatilekha

 
9786207448524: The Unfolded Protein Response Pathway and Lung Cancer: Intervention by phytochemicals
Couverture souple
ISBN 10 : 6207448529 ISBN 13 : 9786207448524
Editeur : LAP LAMBERT Academic Publishing, 2023

Synopsis

Cancer's lethality and the shortcomings of current treatments propel the urgency for effective alternatives. Lung Cancer, a leading cause of malignancy-related deaths, is exacerbated by widespread smoking. Decades of research into cancer biology aim to enhance therapeutic efficacy while minimizing side effects. The Unfolded Protein Response (UPR) pathway, pivotal in maintaining protein homeostasis and responding to ER stress, garners significant interest. The molecular chaperone GRP78, integral in cellular processes during ER stress, holds a multifaceted role in lung cancer biology, influencing survival and treatment resistance. Exploring novel treatments, this chapter investigates plant-derived compounds for antioxidant and anti-inflammatory effects, metabolic regulation, and anti-tumor properties with reduced side effects. Emphasizing UPR in lung cancer, it explores phytochemicals (curcumin, nimbolide, epigallocatechin-3-gallate, emodin) inducing cell death and reducing metastasis. The study further establishes potential connections between these compounds and UPR signaling pathways, including PI3K/Akt, MAPK, NF-κB, Wnt/β-catenin, and STAT3 in cancer cells.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2023
Langue
anglais
ISBN 10 
6207448529
ISBN 13 
9786207448524
Reliure
Broché
Nombre de pages
60
Coordonnées du fabricant
non disponible
Personne responsable
non disponible