FORMULATION AND CHARACTERIZATION oF NICOTINE MOUTH SPRAY: NICOTINE MOUTH SPRAY FORMULATION, OPTIMIZATION USING DOE AND ITS CHARACTERIZATION - Couverture souple

Mehta, Farhad F; Agrawal, Kajal; Jain, Deepti

Couverture souple

ISBN 10 : 6207487699 ISBN 13 : 9786207487691

Editeur : LAP LAMBERT Academic Publishing, 2024

Synopsis

The main aim of our project was to formulate and characterize nicotine mouth sprays. Millions o f people have died and suffered from various diseases like cancer, stroke, blindness, heart problem, and many other chronic diseases by the consumption of raw tobacco and smoking cigarettes.We have developed a nicotine mouth spray formulation as a type of nicotine replacement therapy (NRT) to aid in smoking cessation. This spray can help reduce cravings and alleviate withdrawal symptoms for those who are trying to quit smoking or decrease their tobacco consumption.The optimized formula was generated by the Box- Behnken design under the response surface methodology by the DoE method. Mucoadhesion studies were carried out on the prepared optimized formulation to verify the theoretical prediction. The observed values 0.318 kg was in close agreement with the model prediction: bioadhesive strength- 0.335 kg.These finding reveal that the nicotine mouth spray solution/dispersion would be considered as a successful substitute to various market available NRT formulations, due to its rapid absorption characteristics, which would help general public to quit smoking more effectively.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2024
• Langue: anglais
• ISBN 10: 6207487699
• ISBN 13: 9786207487691
• Reliure: Broché
• Nombre de pages: 100
• Coordonnées du fabricant: non disponible
• Personne responsable: KreGa Onlinehandel GmbH; 4950000000000; info@krega-onlinehandel.de; ; Birkenweg 31; Brakel; 33034; Allemagne