Understanding the clinical evolution of Sickle Cell Anaemia: Genetic determinants associated with the clinical evolution of sickle cell anaemia in patients from the state of Pará - Couverture souple

Da Silva Dos Santos, Aylla Núbia L. M.; Cardoso Costa, Greice De Lemos

Couverture souple

ISBN 10 : 6207532678 ISBN 13 : 9786207532674

Editeur : Our Knowledge Publishing, 2024

Synopsis

Sickle cell anaemia is a disease that has direct implications for the vascular environment due to the polymerisation of haemoglobin S inside the erythrocyte, making them sickle and rigid. The two main phenomena that occur in FA, intravascular haemolysis and vaso-occlusion, generate disturbances in the vasculature of these patients and are responsible for a series of clinical complications. However, vaso-occlusion is a determining factor in clinical evolution, as the endothelium is responsible for vascular homeostasis, and any factor that could upset the balance, such as sickle cell erythrocytes occluding the vessels, triggers a cascade of pathophysiological events. In view of this, our aim was to investigate the influence of genetic polymorphisms that are directly or indirectly involved in vaso-occlusive processes on the clinical variability of sickle cell anaemia.

Détails de l'édition

• Éditeur: Our Knowledge Publishing
• Date d'édition: 2024
• Langue: anglais
• ISBN 10: 6207532678
• ISBN 13: 9786207532674
• Reliure: Broché
• Nombre de pages: 80
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible