Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement: Nanocrystals for Solubility and Dissolution - Couverture souple
Synopsis
The objective of present work was to prepare nanocrystals of Nitrendipin (NTD) to enhance its solubility and dissolution rate with aim of dose reduction and minimising the side effects associated with it’s oral administration. The optimised nanocrystals formulation had particle size 335nm, PDI 0.262, practical yield 85%, and ZP in the range of of -20 to -45mv. X-Ray diffraction studies (XRPD) and Differential scanning calorimetry (DSC) studies suggested nanocrystal formation and absence of crystalline peaks, indicating loss of crystallinity, additionally confirmed by scanning electron microscopy (SEM). Nanocrystals showed 30.45 fold enhancements in aqueous solubility, and 38.5 fold in phosphate buffer pH 1.2, as compared to pure NTD. In vitro release studies have demonstrated 96.186% cumulative drug release within 60 min from nanocrystals compared to 22.17% from pure NTD. Stable NTD nanocrystals formulated by anti-solvent precipitation method shows improved solubility and dissolution. It has been concluded that NTD nanocrystals were obtained with significant improvement in saturation solubility and drug losing it’s crystalline nature, when compared with plain drug.
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Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement
Edité par
LAP LAMBERT Academic Publishing Mai 2024, 2024
ISBN 10 : 6207640497
ISBN 13 : 9786207640492
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 64 pp. Englisch. N° de réf. du vendeur 9786207640492
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Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement
Edité par
LAP Lambert Academic Publishing, 2024
ISBN 10 : 6207640497
ISBN 13 : 9786207640492
Neuf
Couverture souple
Vendeur : moluna, Greven, Allemagne
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Shinde AnilkumarDr. Anilkumar J. Shinde, M.Pharm Ph.D (Pharmacy) from Shivaji University, Kolhapur. He has 26 years experience in marketing, teaching & researching. Presently he is working as Associate Professor in Pharmaceutics Depa. N° de réf. du vendeur 1692683694
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Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement
Edité par
LAP LAMBERT Academic Publishing Mai 2024, 2024
ISBN 10 : 6207640497
ISBN 13 : 9786207640492
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. Neuware -The objective of present work was to prepare nanocrystals of Nitrendipin (NTD) to enhance its solubility and dissolution rate with aim of dose reduction and minimising the side effects associated with it¿s oral administration. The optimised nanocrystals formulation had particle size 335nm, PDI 0.262, practical yield 85%, and ZP in the range of of -20 to -45mv. X-Ray diffraction studies (XRPD) and Differential scanning calorimetry (DSC) studies suggested nanocrystal formation and absence of crystalline peaks, indicating loss of crystallinity, additionally confirmed by scanning electron microscopy (SEM). Nanocrystals showed 30.45 fold enhancements in aqueous solubility, and 38.5 fold in phosphate buffer pH 1.2, as compared to pure NTD. In vitro release studies have demonstrated 96.186% cumulative drug release within 60 min from nanocrystals compared to 22.17% from pure NTD. Stable NTD nanocrystals formulated by anti-solvent precipitation method shows improved solubility and dissolution. It has been concluded that NTD nanocrystals were obtained with significant improvement in saturation solubility and drug losing it¿s crystalline nature, when compared with plain drug.Books on Demand GmbH, Überseering 33, 22297 Hamburg 64 pp. Englisch. N° de réf. du vendeur 9786207640492
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Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement : Nanocrystals for Solubility and Dissolution
Edité par
LAP LAMBERT Academic Publishing, 2024
ISBN 10 : 6207640497
ISBN 13 : 9786207640492
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The objective of present work was to prepare nanocrystals of Nitrendipin (NTD) to enhance its solubility and dissolution rate with aim of dose reduction and minimising the side effects associated with it's oral administration. The optimised nanocrystals formulation had particle size 335nm, PDI 0.262, practical yield 85%, and ZP in the range of of -20 to -45mv. X-Ray diffraction studies (XRPD) and Differential scanning calorimetry (DSC) studies suggested nanocrystal formation and absence of crystalline peaks, indicating loss of crystallinity, additionally confirmed by scanning electron microscopy (SEM). Nanocrystals showed 30.45 fold enhancements in aqueous solubility, and 38.5 fold in phosphate buffer pH 1.2, as compared to pure NTD. In vitro release studies have demonstrated 96.186% cumulative drug release within 60 min from nanocrystals compared to 22.17% from pure NTD. Stable NTD nanocrystals formulated by anti-solvent precipitation method shows improved solubility and dissolution. It has been concluded that NTD nanocrystals were obtained with significant improvement in saturation solubility and drug losing it's crystalline nature, when compared with plain drug. N° de réf. du vendeur 9786207640492
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Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement | Nanocrystals for Solubility and Dissolution
Edité par
LAP LAMBERT Academic Publishing, 2024
ISBN 10 : 6207640497
ISBN 13 : 9786207640492
Neuf
Taschenbuch
Vendeur : preigu, Osnabrück, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement | Nanocrystals for Solubility and Dissolution | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2024 | LAP LAMBERT Academic Publishing | EAN 9786207640492 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 129351376
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