Articles liés à The Beta Secretase Enzyme BACE1 target for Alzheimer’...

The Beta Secretase Enzyme BACE1 target for Alzheimer’s Disease-Secret - Couverture souple

Shah, Hirak; Vegad, Kunjal; Shah, Dhwani

 
9786208011017: The Beta Secretase Enzyme BACE1 target for Alzheimer’s Disease-Secret
Couverture souple
ISBN 10 : 6208011019 ISBN 13 : 9786208011017
Editeur : LAP LAMBERT Academic Publishing, 2024

Synopsis

Despite the consensus among seniors and primary care physicians on the importance of short cognitive assessments for dementia detection, only half of seniors have been assessed, with just 16 percent undergoing regular evaluations. Educational initiatives are available to increase the use of these assessments in primary care, according to Alzheimer's Association surveys.Alzheimer's disease (AD) pathogenesis involves oxidative stress/mitochondrial dysfunction, amyloid/tau toxicity, and cholinergic dysfunction. Among the therapeutic targets, Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is crucial due to its role in the amyloidogenic cleavage of APP, generating Amyloid β (Aβ). BACE1, a β-secretase, also cleaves substrates like neuregulin and the β2 subunit of the voltage-gated sodium channel, essential for brain development and function. BACE1 is modulated post-translationally by factors linked to both physiological and pathological functions. However, developing small molecule inhibitors for BACE1 has posed challenges for AD treatment.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2024
Langue
anglais
ISBN 10 
6208011019
ISBN 13 
9786208011017
Reliure
Broché
Nombre de pages
64
Coordonnées du fabricant
non disponible
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