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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques - Couverture souple
Synopsis
Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 μg/ml) limits its bioavailability. This study aimed to improve Irbesartan’s solubility through solid dispersions using carriers like β-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. β-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug’s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that β-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using β-cyclodextrin in solid dispersions effectively enhances Irbesartan’s solubility and therapeutic potential in treating hypertension.
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Edité par
LAP LAMBERT Academic Publishing, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Couverture souple
Vendeur : Ria Christie Collections, Uxbridge, Royaume-Uni
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Etat : New. In. N° de réf. du vendeur ria9786208119713_new
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Edité par
LAP LAMBERT Academic Publishing, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Couverture souple
Vendeur : California Books, Miami, FL, Etats-Unis
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Etat : New. N° de réf. du vendeur I-9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion
Edité par
LAP LAMBERT Academic Publishing Sep 2024, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 84 pp. Englisch. N° de réf. du vendeur 9786208119713
Quantité disponible : 2 disponible(s)
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Enhancing Irbesartan Bioavailability via Solid Dispersion : Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Edité par
LAP LAMBERT Academic Publishing, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 ¿g/ml) limits its bioavailability. This study aimed to improve Irbesartan¿s solubility through solid dispersions using carriers like ¿-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. ¿-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug¿s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that ¿-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using ¿-cyclodextrin in solid dispersions effectively enhances Irbesartan¿s solubility and therapeutic potential in treating hypertension. N° de réf. du vendeur 9786208119713
Quantité disponible : 1 disponible(s)
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Enhancing Irbesartan Bioavailability via Solid Dispersion
Edité par
LAP LAMBERT Academic Publishing Sep 2024, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. Neuware -Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 ¿g/ml) limits its bioavailability. This study aimed to improve Irbesartan¿s solubility through solid dispersions using carriers like ¿-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. ¿-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug¿s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that ¿-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using ¿-cyclodextrin in solid dispersions effectively enhances Irbesartan¿s solubility and therapeutic potential in treating hypertension.Books on Demand GmbH, Überseering 33, 22297 Hamburg 84 pp. Englisch. N° de réf. du vendeur 9786208119713
Quantité disponible : 2 disponible(s)
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Edité par
LAP LAMBERT Academic Publishing, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Couverture souple
Vendeur : Books Puddle, New York, NY, Etats-Unis
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Etat : New. N° de réf. du vendeur 26403814798
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Edité par
LAP LAMBERT Academic Publishing, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Couverture souple
Vendeur : Majestic Books, Hounslow, Royaume-Uni
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Etat : New. Print on Demand. N° de réf. du vendeur 409339473
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Edité par
LAP LAMBERT Academic Publishing, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Couverture souple
Vendeur : Biblios, Frankfurt am main, HESSE, Allemagne
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Etat : New. PRINT ON DEMAND. N° de réf. du vendeur 18403814788
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Enhancing Irbesartan Bioavailability via Solid Dispersion (Paperback)
Edité par
LAP Lambert Academic Publishing, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Paperback
Vendeur : AussieBookSeller, Truganina, VIC, Australie
Évaluation du vendeur 5 sur 5 étoiles
Paperback. Etat : new. Paperback. Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 mg/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like b-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. b-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that b-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using b-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. N° de réf. du vendeur 9786208119713
Quantité disponible : 1 disponible(s)
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Enhancing Irbesartan Bioavailability via Solid Dispersion (Paperback)
Edité par
LAP Lambert Academic Publishing, 2024
ISBN 10 : 6208119715
ISBN 13 : 9786208119713
Neuf
Paperback
Vendeur : CitiRetail, Stevenage, Royaume-Uni
Évaluation du vendeur 5 sur 5 étoiles
Paperback. Etat : new. Paperback. Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 mg/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like b-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. b-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that b-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using b-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability. N° de réf. du vendeur 9786208119713
Quantité disponible : 1 disponible(s)