Articles liés à Chimeric Vaccine Design Against Melioidosis via Subtractive...

Chimeric Vaccine Design Against Melioidosis via Subtractive Proteomics - Couverture souple

Ahmad Khan, Mohammad Kalim; Akhtar, Salman; Maurya, Shalini

 
9786208417253: Chimeric Vaccine Design Against Melioidosis via Subtractive Proteomics
Couverture souple
ISBN 10 : 6208417252 ISBN 13 : 9786208417253
Editeur : LAP Lambert Academic Publishing, 2024

Synopsis

Subtractive proteomics and reverse vaccinology were employed to design a chimeric multi-epitope vaccine against melioidosis, a severe infectious disease caused by the multidrug-resistant bacterium, Burkholderia pseudomallei. From 21 non-redundant pathogen proteomes, four proteins were selected as vaccine candidates based on essentiality, virulence, non-homology to humans, structural availability, subcellular localization, and antigenicity. The major histocompatibility complex class I, II, and B-cell epitopes were predicted and evaluated for immunogenicity, solubility, allergenicity, and hydrophilicity. A chimeric vaccine was constructed using the epitopes, adjuvants, linkers, and PADRE sequences. Docking and molecular dynamics simulations confirmed interactions between HLA alleles and TLR4, indicating the potential to elicit an immune response, demonstrating the utility of computational tools in developing vaccines against B. pseudomallei.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2024
Langue
anglais
ISBN 10 
6208417252
ISBN 13 
9786208417253
Reliure
Broché
Nombre de pages
120
Coordonnées du fabricant
non disponible
Personne responsable
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