Articles liés à Understanding Amyotrophic Lateral Sclerosis: Causes...

Understanding Amyotrophic Lateral Sclerosis: Causes and Management: Understanding Causes, Managing Care,and Exploring Treatment Advances inAmyotrophic Lateral Sclerosis - Couverture souple

El-Banna, Mona

 
9786208420321: Understanding Amyotrophic Lateral Sclerosis: Causes and Management: Understanding Causes, Managing Care,and Exploring Treatment Advances inAmyotrophic Lateral Sclerosis
Couverture souple
ISBN 10 : 6208420326 ISBN 13 : 9786208420321
Editeur : LAP LAMBERT Academic Publishing, 2025

Synopsis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by muscle weakness, atrophy, fasciculations, and spasticity due to motor neuron degeneration. Symptoms progress from focal weakness to difficulties in speaking, swallowing, and breathing, with eventual paralysis. The disease arises from mechanisms such as disrupted RNA metabolism (e.g., TDP-43 and FUS mutations), cytoskeletal and axonal transport defects (e.g., PFN1, TUBA4A mutations), excitotoxicity, and oxidative stress. While incurable, treatments like Riluzole and Edaravone can modestly slow progression, and supportive care—such as non-invasive ventilation, feeding tubes, and physical therapy—helps manage symptoms. Emerging therapies, including gene and RNA-targeted approaches, hold promise for the future.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2025
Langue
anglais
ISBN 10 
6208420326
ISBN 13 
9786208420321
Reliure
Broché
Nombre de pages
60
Coordonnées du fabricant
non disponible
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