Mechanism of Bone Destruction - Couverture souple

Gupta, Shivani; Agarwal, Prerna; Agarwal, Ashutosh

Couverture souple

ISBN 10 : 620844523X ISBN 13 : 9786208445232

Editeur : LAP LAMBERT Academic Publishing, 2025

Synopsis

Bone destruction is central to conditions like osteoporosis, rheumatoid arthritis, and cancers with bone metastases. It results from an imbalance between bone resorption by osteoclasts and formation by osteoblasts. Osteoclast activity is regulated by the RANK/RANKL/OPG axis, where an increased RANKL/OPG ratio promotes osteoclastogenesis. Inflammatory cytokines (e.g., TNF-α, IL-1, IL-6) enhance RANKL expression and osteoclast survival. In cancer, tumor-derived factors like PTHrP and prostaglandins further drive RANKL-mediated bone loss. Bone resorption releases growth factors such as TGF-β, fueling tumor growth and perpetuating degradation. Enzymes like MMPs and cathepsin K degrade bone matrix, while hypoxia and mechanical stress also contribute. Understanding these mechanisms supports treatments like bisphosphonates, RANKL inhibitors (e.g., denosumab), and anti-cytokine therapies, which effectively reduce bone loss.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2025
• Langue: anglais
• ISBN 10: 620844523X
• ISBN 13: 9786208445232
• Reliure: Broché
• Nombre de pages: 88
• Coordonnées du fabricant: non disponible
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