Articles liés à ROLE OF BISPHOSPHONATES IN BONE HOMEOSTASIS: A Systematic...

ROLE OF BISPHOSPHONATES IN BONE HOMEOSTASIS: A Systematic Review - Couverture souple

AGGARWAL, DR. KANIKA; GUPTA, DR. GUNJAN; Tandon, Dr. Priyanka

 
9786208447106: ROLE OF BISPHOSPHONATES IN BONE HOMEOSTASIS: A Systematic Review
Couverture souple
ISBN 10 : 6208447100 ISBN 13 : 9786208447106
Editeur : LAP LAMBERT Academic Publishing, 2025

Synopsis

Bisphosphonates play a critical role in maintaining bone homeostasis by inhibiting the activity of osteoclasts, the cells responsible for bone resorption. By reducing the breakdown of bone tissue, these drugs help preserve bone density and strength, which is essential in conditions where bone loss is accelerated, such as osteoporosis, Paget’s disease, and bone metastases. Bisphosphonates bind strongly to bone mineral and are taken up by osteoclasts during resorption, leading to their dysfunction and eventual apoptosis. This shifts the balance of bone remodelling toward bone formation by osteoblasts, promoting overall skeletal stability. Additionally, bisphosphonates help regulate the bone remodelling process by influencing signalling pathways like the RANK/RANKL/OPG system, further contributing to the suppression of osteoclast activity and supporting long-term bone health.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2025
Langue
anglais
ISBN 10 
6208447100
ISBN 13 
9786208447106
Reliure
Broché
Nombre de pages
56
Coordonnées du fabricant
non disponible
Personne responsable
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