NEW METHOD DEVELOPMENT AND VALIDATION OF BEMPEDOIC ACID: Second Edition - Couverture souple

Karanam, Sridevi Ranjitha; Yarguntla, Srinivasa Rao; Kollabatthula, Vara Prasada Rao

Couverture souple

ISBN 10 : 6209602290 ISBN 13 : 9786209602290

Editeur : LAP LAMBERT Academic Publishing, 2026

Synopsis

A Visible Spectrophotometric method has been developed and validated for the quantitative measurement of Bempedoic acid in bulk and tablet dosage forms. The process is based on the production of a colored complex in the presence of Ferric chloride between Bempedoic acid and MBTH (3-methyl-2-benzothiazolinone Hydrazone). At 663 nm, the colored complex was spectrophotometrically measured. The correlation coefficient (r2) of 0.999 revealed that the approach is linear in the concentration range of 10-60 µg/mL. It was discovered that the limits of detection (LOD) and quantitation (LOQ) were 2.169 µg/mL and 6.572 µg/mL, respectively. For both intra-day and inter-day precision studies, the approach was proven to be precise with a percent relative standard deviation (%RSD) less than 2.0%. Recovery experiments were used to assess the method's accuracy, and it was discovered that the average percentage of recovery fell between 98.0 and 102.0%. The results of the suggested approach were compared to those of the reference method for the accurate determination of Bempedoic acid in tablet dosage forms.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2026
• Langue: anglais
• ISBN 10: 6209602290
• ISBN 13: 9786209602290
• Reliure: Broché
• Nombre de pages: 76
• Coordonnées du fabricant: non disponible
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