Formulation and Evaluation of Mucoadhesive Drug Delivery Systems: A Novel Approach to Overcome First-Pass Metabolism of Salbutamol Sulphate via Mucoadhesive Buccal Tablets - Couverture souple

Kulkarni, Gururaj S; A S., Ankithasirinayana; Choudhary, Vikram T

 
9786209606922: Formulation and Evaluation of Mucoadhesive Drug Delivery Systems: A Novel Approach to Overcome First-Pass Metabolism of Salbutamol Sulphate via Mucoadhesive Buccal Tablets
Couverture souple
ISBN 10 : 620960692X ISBN 13 : 9786209606922
Editeur : LAP LAMBERT Academic Publishing, 2026

Synopsis

Buccal drug delivery bypasses hepatic first-pass metabolism, offering improved bioavailability over conventional oral administration. This work presents the formulation and evaluation of mucoadhesive buccal tablets of Salbutamol sulphate using natural polymers-Xanthan gum, Guar gum, and Sodium alginate.FTIR and DSC studies confirmed drug-excipient compatibility. Thirty formulations prepared by direct compression, with Ethyl cellulose as a backing layer, met all standard physicochemical parameters. In-vitro dissolution showed up to 100.81% drug release over 8 hours following zero-order kinetics. In-vivo studies on rabbits confirmed 87.37% buccal absorption with sustained plasma levels and higher AUC than oral administration. Good in-vitro/in-vivo correlation and three-month stability were demonstrated.These results establish mucoadhesive buccal tablets as an effective, stable, and bioavailable dosage form for asthma management.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2026
Langue
anglais
ISBN 10 
620960692X
ISBN 13 
9786209606922
Reliure
Broché
Nombre de pages
124
Coordonnées du fabricant
non disponible
Personne responsable
non disponible