Articles liés à NANOPARTICLE-BASED DELIVERY SYSTEMS FOR HYPERTENSION...

NANOPARTICLE-BASED DELIVERY SYSTEMS FOR HYPERTENSION MANAGEMENT: DEVELOPMENT AND CHARACTERIZATION OF VALSARTAN NANOPARTICLES - Couverture souple

Prabha, R Uma; A, Varshitha; K, Manohar

 
9786209785016: NANOPARTICLE-BASED DELIVERY SYSTEMS FOR HYPERTENSION MANAGEMENT: DEVELOPMENT AND CHARACTERIZATION OF VALSARTAN NANOPARTICLES
Couverture souple
ISBN 10 : 6209785018 ISBN 13 : 9786209785016
Editeur : LAP LAMBERT Academic Publishing, 2026

Synopsis

The book chapter focuses on the formulation and evaluation of mucoadhesive buccal tablets of terbutaline sulphate for improved management of bronchial asthma. Conventional oral drug delivery systems often face limitations such as first-pass hepatic metabolism, enzymatic degradation, and variable gastrointestinal absorption, which reduce drug bioavailability and therapeutic efficacy. To overcome these challenges, the study explores mucoadhesive buccal drug delivery systems (MBDS) as an alternative route for systemic drug delivery. The buccal route offers several advantages, including direct absorption through the buccal mucosa, avoidance of first-pass metabolism, rapid onset of action, and improved patient compliance. In this work, mucoadhesive buccal tablets of terbutaline sulphate were formulated using suitable polymers, particularly natural polymers such as guar gum, to enhance adhesion and sustain drug release. The formulation process involved optimising the polymer concentration to achieve desirable swelling behaviour, mucoadhesive strength, and controlled drug release.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2026
Langue
anglais
ISBN 10 
6209785018
ISBN 13 
9786209785016
Reliure
Broché
Nombre de pages
160
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
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