New method development and validation of sensitive LC-MS/MS method: for Quantification of nitrosoamine impurities in Glimepride active ingredient - Couverture souple

Venkata Veerendra Prasad, Karedla; Nageswara Rao, Tentu; Rajasekhar Reddy, G

Couverture souple

ISBN 10 : 663025810X ISBN 13 : 9786630258103

Editeur : LAP Lambert Academic Publishing, 2026

Synopsis

The analysis of nitrosoamine impurities using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a critical process in pharmaceutical and food safety testing. Nitrosoamines are known for their potential carcinogenic properties, making their detection and quantification essential. LC-MS/MS offers high sensitivity and specificity, allowing for the effective separation and identification of these compounds in complex matrices. The methodology typically involves sample preparation, which may include extraction and purification steps to isolate nitrosoamines from the sample matrix. Following this, the samples are subjected to LC-MS/MS, where the liquid chromatography component separates the nitrosoamines based on their chemical properties, while the tandem mass spectrometry provides precise mass-to-charge ratio measurements, enabling accurate identification and quantification. Key insights from recent studies indicate that optimizing the chromatographic conditions, such as the choice of stationary phase and mobile phase composition, significantly enhances the resolution and sensitivity of the analysis.

Détails de l'édition

• Éditeur: LAP Lambert Academic Publishing
• Date d'édition: 2026
• Langue: anglais
• ISBN 10: 663025810X
• ISBN 13: 9786630258103
• Reliure: Tapa blanda
• Nombre de pages: 68
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible