The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis - Couverture rigide
Synopsis
As pointed out by Auerbach in 1991 "Perhaps the most consistent limitation to progress in angiogenesis research has been the availability of simple, reliable, reproducible, quantitative assays of the angiogenesis response." In vitro angiogenesis assays, based on endothelial cell cultures or tissue explant, focus on isolated endothelial cell functions (e.g., endothelial cell proliferation, migration, or invasion) and do not examine the coordination of cell functions required for a successful angiogenic response (Jain et al., 1997; Auerbach et al., 2000). Although in vitro angiogenesis assays have been useful for identi cation of potential molecular targets to block endothelial cell responses and preliminary screening of novel pharmacological agents, they frequently cannot be correlated with in vivo angiogenesis measurements. This is most likely the result of the c- plex and multiple cellular mechanism evoked during new blood vessel formation in vivo. In vitro assays cannot be considered conclusive and the activity of a compound must be con rmed in other assays of increasing complexity, including in vivo assays of angiogenesis, angiogenic-dependent tumor growth, and metastasis.
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
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Springer, 2010
ISBN 10 : 9048138434
ISBN 13 : 9789048138432
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Hardcover. Etat : As New. No Jacket. Pages are clean and are not marred by notes or folds of any kind. ~ ThriftBooks: Read More, Spend Less. N° de réf. du vendeur G9048138434I2N00
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis (eng)
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis: The CAM assay in the study of angiogenesis and metastasis
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
Edité par
Springer Netherlands Feb 2010, 2010
ISBN 10 : 9048138434
ISBN 13 : 9789048138432
Neuf
Couverture rigide
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which serves as a gas exchange surface and its function is supported by a dense capillary network. Because of its extensive vascularization and easy accessibility, the CAM has been broadly used to study the morpho-functional aspects of the angiogenesis process in vivo and to investigate the efficacy and mechanisms of action of pro-angiogenic and anti-angiogenic natural and synthetic molecules. The CAM is a suitable site for transplanting tissues, which can survive and develop in the CAM by peripheral anastomoses between graft and original CAM vasculature or by new angiogenic vessels grown from the CAM that invade the graft. While the formation of peripheral anastomoses between host and pre-existing donor vessels is the main, and the most common, mechanism involved in the revascularization of embryonic grafts, the growth of CAM-derived vessels into the graft is only stimulated in tumor grafts. The CAM has long been a favored system for the study of tumor angiogenesis and metastasis, because at this stage the chick immunocompetence system is not fully developed and the conditions for rejection have not been established. Tumors remain avascular for 72 h, after which they are penetrated by new blood vessels and begin a phase of rapid growth. Also, delivery of tumor cells onto the CAM allows the fine study of the effects of tumor derived angiogenic growth factors on blood vessel structure and functionality. The CAM may also used to verify the ability to inhibit the growth of capillaries by implanting tumors onto the CAM and by comparing tumor growth and vascularization with or without the administration of an anti-angiogenic molecule. Other studies using the tumor cells/CAM model have focused on the invasion of the chorionic epithelium and the blood vessels by tumor cells. The cells invade the epithelium and the mesenchymal connective tissue below, where they are found in the form of a dense bed of blood vessels, which is a target for intravasation. 136 pp. Englisch. N° de réf. du vendeur 9789048138432
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
Edité par
Springer Netherlands, 2010
ISBN 10 : 9048138434
ISBN 13 : 9789048138432
Neuf
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Several in vivo assays are currently used in the study of angiogenesis and antiangiogenesisThe chick embryo chorioallantoic membrane is one of the most common and versatile assay to study angiogenesis and antiangiogenesis in vivoAngiogenesi. N° de réf. du vendeur 5817826
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
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Etat : New. pp. x + 119. N° de réf. du vendeur 261401179
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
impression à la demandeVendeur : Biblios, Frankfurt am main, HESSE, Allemagne
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Etat : New. PRINT ON DEMAND pp. x + 119. N° de réf. du vendeur 181401169
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis: The Cam Assay in the Study of Angiogenesis and Metastasis
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Hardcover. Etat : Brand New. 1st edition. 124 pages. 9.25x6.25x0.50 inches. In Stock. N° de réf. du vendeur x-9048138434
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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
Edité par
Springer Netherlands, Springer Feb 2010, 2010
ISBN 10 : 9048138434
ISBN 13 : 9789048138432
Neuf
Couverture rigide
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
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Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -As pointed out by Auerbach in 1991 ¿Perhaps the most consistent limitation to progress in angiogenesis research has been the availability of simple, reliable, reproducible, quantitative assays of the angiogenesis response.¿ In vitro angiogenesis assays, based on endothelial cell cultures or tissue explant, focus on isolated endothelial cell functions (e.g., endothelial cell proliferation, migration, or invasion) and do not examine the coordination of cell functions required for a successful angiogenic response (Jain et al., 1997; Auerbach et al., 2000). Although in vitro angiogenesis assays have been useful for identi cation of potential molecular targets to block endothelial cell responses and preliminary screening of novel pharmacological agents, they frequently cannot be correlated with in vivo angiogenesis measurements. This is most likely the result of the c- plex and multiple cellular mechanism evoked during new blood vessel formation in vivo. In vitro assays cannot be considered conclusive and the activity of a compound must be con rmed in other assays of increasing complexity, including in vivo assays of angiogenesis, angiogenic-dependent tumor growth, and metastasis.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 136 pp. Englisch. N° de réf. du vendeur 9789048138432
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