Direct Methods for Solving Macromolecular Structures: (Closed)) - Couverture souple

Couverture souple

ISBN 10 : 9048149940 ISBN 13 : 9789048149940

Editeur : Springer, 2010

Synopsis

This book of the proceedings of the 1997 NATO Advanced Study Institute (ASI) on Direct Methods for Solving Macromolecular Structures was assembled from the lecturers' contributions and represents a comprehensive and in-depth overview of crystallographic structure determination methods for macromolecules. While having a focus based on the direct methods, the Institute adopted an inclusive and broad perspective. Thus, both direct and experimental phasing techniques are presented in this book, highlighting their complementarities and synergies. As weil, methodologies spanning the full crystallographic image reconstruction process - from low resolution envelope definition to high resolution atomic refinement- are discussed. The first part of the book introduces the array of tools currently used in structure determination, whether originating from a mathematical, computational or experimental framework. This section of the book displays the variety and ingenuity of old and new phasing approaches developed to solve increasingly complex structures. Some of the contributions focus on recent developments and/or implementations that have given older approaches a new life. A case in point is the re-implementation of Buerger's superposition approach, which is now solving protein structures. Another beautiful example is found in the introduction to the traditional multiple isomorphous replacement approach where new techniques, such as site-directed mutagenesis and the use of inert gases in the preparation of heavy atom derivatives, are described. Equally impressive are the presentations of newer approaches, which take advantage of advances on the experimental front (e. g.

A propos du livre

Présentation de l'éditeur

The first part of the book introduces the array of tools currently in use in structure determination, originating from mathematical, computational and experimental approaches. It displays the variety and ingenuity of old and new phasing approaches developed to solve increasingly complex structures. Some of the papers focus on recent developments that have given older methods a new lease of life. Equally impressive are the presentations of newer approaches which take advantage of recent experimental, mathematical and computational advances.
The second part of the book focuses on applications to macromolecular structures, displaying the incredible progress that has been achieved in recent years.
The book concludes with a series of presentations on the latest developments, providing a view of the newest phasing methodologies. It offers the promise of many more achievements yet to come.

Détails de l'édition

• Éditeur: Springer
• Date d'édition: 2010
• Langue: anglais
• ISBN 10: 9048149940
• ISBN 13: 9789048149940
• Reliure: Broché
• Numéro d'édition: 1
• Nombre de pages: 540
• Éditeur: Fortier S.
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne