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Virtual Screening: An Alternative Or Complement To High Throughput Screening?: Proceedings Of The Workshop 'New Approaches In Drug Design And . . . Rauischholzhausen, Germany, March 15-18, 1999 - Couverture souple
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- ÉditeurSpringer
- Date d'édition2010
- ISBN 10 9048155843
- ISBN 13 9789048155842
- ReliureBroché
- Numéro d'édition1
- Nombre de pages312
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Virtual Screening: An Alternative or Complement to High Throughput Screening?
Edité par
Springer Netherlands Dez 2010
(2010)
ISBN 10 : 9048155843
ISBN 13 : 9789048155842
Neuf
Taschenbuch
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Description du livre Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this request which is summarized in this publication. 312 pp. Englisch. N° de réf. du vendeur 9789048155842
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Virtual Screening: An Alternative or Complement to High Throughput Screening?
Edité par
Springer Netherlands
(2010)
ISBN 10 : 9048155843
ISBN 13 : 9789048155842
Neuf
Couverture souple
Quantité disponible : > 20
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Evaluation vendeur
Description du livre Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful . N° de réf. du vendeur 5819439
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Virtual Screening: An Alternative or Complement to High Throughput Screening? : Proceedings of the Workshop ¿New Approaches in Drug Design and Discovery¿, special topic ¿Virtual Screening¿, Schloß Rauischholzhausen, Germany, March 15¿18, 1999
Edité par
Springer Netherlands
(2010)
ISBN 10 : 9048155843
ISBN 13 : 9789048155842
Neuf
Taschenbuch
Quantité disponible : 1
Vendeur :
Evaluation vendeur
Description du livre Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this request which is summarized in this publication. N° de réf. du vendeur 9789048155842
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Virtual Screening: An Alternative or Complement to High Throughput Screening
Edité par
Springer
(2010)
ISBN 10 : 9048155843
ISBN 13 : 9789048155842
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Description du livre Paperback. Etat : Brand New. reprint edition. 308 pages. 9.00x6.00x0.74 inches. In Stock. N° de réf. du vendeur zk9048155843
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