Targeted Radionuclide Tumor Therapy: Biological Aspects - Couverture souple

Couverture souple

ISBN 10 : 9048179564 ISBN 13 : 9789048179565

Editeur : Springer, 2010

Synopsis

The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.

A propos du livre

Présentation de l'éditeur

The ambition of the editors of this volume is to enable deeper insights into the process of improving targeted radionuclide therapy. They believe that the time has now come when targeted therapy can soon be added to standard oncology treatment regimens.

Détails de l'édition

• Éditeur: Springer
• Date d'édition: 2010
• Langue: anglais
• ISBN 10: 9048179564
• ISBN 13: 9789048179565
• Reliure: Broché
• Numéro d'édition: 1
• Nombre de pages: 416
• Éditeur: Stigbrand Torgny, Carlsson Jorgen, Adams Gregory P.
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne