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Recent Advances in Animal Cell and Tissue Culture
Edité par
Globus Press, 2012
ISBN 10 : 9382074171
ISBN 13 : 9789382074175
Neuf
Couverture rigide
Edition originale
Vendeur : Vedams eBooks (P) Ltd, New Delhi, Inde
Évaluation du vendeur 4 sur 5 étoiles
Hardcover. Etat : New. Etat de la jaquette : New. 1st Edition. Contents: Preface. 1. Human stem cell. 2. Future growth and directions. 3. Applied genetics. 4. Molecular cloning. 5. Transvaginal oocyte retrieval. 6. Biological functions and evolution. Bibliography. Index. There has been a rapid increase in the number and demand for approved biopharmaceuticals produced from animal cell culture processes over the last few years. In part this has been due to the efficacy of several humanized monoclonal antibodies that are required at large doses for therapeutic use. There have also been several identifiable advances in animal cell technology that has enabled efficient biomanufacture of these products. Gene vector systems allow high specific protein expression and some minimize the undesirable process of gene silencing that may occur in prolonged culture. Characterization of cellular metabolism and physiology has enabled the design of fed-batch and perfusion bioreactor processes that has allowed a significant improvement in product yield, some of which are now approaching 5 g/L. Many of these processes are now being designed in serum-free and animal component free media to ensure that products are not contaminated with the adventitious agents found in bovine serum. There are several areas that can be identified that could lead to further improvement in cell culture systems. In the preparation of this book it has been the author's aim to keep in mind not only the requirements of students in this subject but as well the needs of student. N° de réf. du vendeur 110481
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