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Synopsis
The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.
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Présentation de l'éditeur
Written by active investigators who have made important contributions in their respective areas, this book offers an up-to-date and comprehensive review of the latest advances in DNA damage sensing, signaling and repair.
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The DNA Damage Response: Implications on Cancer Formation and Treatment (eng)
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The DNA Damage Response: Implications on Cancer Formation and Treatment
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Springer Netherlands Nov 2014, 2014
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the 'DNA damage response'. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci c damaging agents, immunode ciency, genomic instability, cancer predisposition and premature aging. The nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving eld, and the advances in our understanding of the complex network of processes that respond to DNA damage. 464 pp. Englisch. N° de réf. du vendeur 9789400779952
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The DNA Damage Response: Implications on Cancer Formation and Treatment
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Offers up-to-date and comprehensive review of latest advances in DNA damage sensing, signalling and repair fieldDescribes current bottlenecks and future directionsDiscusses the relationship between DNA damage repair and cancerWritten. N° de réf. du vendeur 5828165
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DNA Damage Response: Implications on Cancer Formation and Treatment : Implications on Cancer Formation and Treatment
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Taschenbuch. Etat : Neu. The DNA Damage Response: Implications on Cancer Formation and Treatment | Kum Kum Khanna (u. a.) | Taschenbuch | xii | Englisch | 2014 | Springer | EAN 9789400779952 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. N° de réf. du vendeur 105011681
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - The eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the 'DNA damage response'. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci c damaging agents, immunode ciency, genomic instability, cancer predisposition and premature aging. The nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving eld, and the advances in our understanding of the complex network of processes that respond to DNA damage. N° de réf. du vendeur 9789400779952
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The DNA Damage Response: Implications on Cancer Formation and Treatment
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ISBN 10 : 940077995X
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Neuf
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the ¿DNA damage response¿. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci c damaging agents, immunode ciency, genomic instability, cancer predisposition and premature aging. The nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 464 pp. Englisch. N° de réf. du vendeur 9789400779952
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