DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases: (closed)) - Couverture souple

Couverture souple

ISBN 10 : 9401065969 ISBN 13 : 9789401065962

Editeur : Springer, 2011

Synopsis

The past decade has witnessed a burst of activity and interest in the discovery and design of drugs that cleave DNA and RNA with sequence- specificity. This interest stems from the potential of this class of compounds to be useful as therapeutics agents, in particular in the field of the treatment of cancer and viral diseases. Further, a side benefit of such studies is the discovery of novel mechanisms and uses of such agents as tools in the study of structure and function of nucleic acids. Up to now, no international meeting has been organized to recognize the immense progress that has been made in this field. The field of DNA and RNA cleavage by natural and chemical drugs now includes researchers working with rather dissimilar agents but with common underlying mechanisms of DNA damage. Until recently, these scientists were working in separate, apparently unrelated areas, such as the enediyne antibiotics and their synthetic analogues, bleomycin-metal complexes, metal-drug complexes, ribozymes and ribozyme mimics, and antisense and antigene oligonucleotides, etc. It is now clear that these research areas have in common strategies and targets. Researchers representing these areas worked together at this workshop where these common interests were discussed and scientific ideas modified and criticized. Such a workshop should lead to new research approaches and collaborative interactions, and is expected to significantly enhance the progress in the field of DNA and RNA cleavage.

A propos du livre

Présentation de l'éditeur

The past decade has witnessed a burst of activity and interest in the discovery and design of drugs that cleave DNA and RNA with sequence specificity. This class of compounds can be used as therapeutic agents, especially in the treatment of cancer and viral diseases. Novel mechanisms have also been discovered, allowing such agents to be used as tools in the study of the structure and function of nucleic acids. The major advances have been achieved with enediyne antibiotics and their synthetic analogues, bleomycin-metal complexes, metal-drug complexes, ribozymes and their mimics, and antisense and antigene oligonucleotides. This, the first book devoted to the area, contains 25 chapters produced by experts on DNA cleavage by enediyne molecules, the mechanism of action of bleomycin, the paradigm of DNA cleavers site-specific DNA and RNA cleavage and its mechanism, RNA cleavage by RNase H, RNA hydrolysis by ribozymes and metal complexes, and redox regulation of the human immunodeficiency virus. Audience: Chemists, biochemists, pharmacologists and molecular biologists involved in the development of new research approaches in the area of DNA and RNA cleavage.

Détails de l'édition

• Éditeur: Springer
• Date d'édition: 2011
• Langue: anglais
• ISBN 10: 9401065969
• ISBN 13: 9789401065962
• Reliure: Broché
• Nombre de pages: 404
• Éditeur: Meunier B.
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne