Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells - Couverture rigide

Zhao, Xiaoyang

 
9789401788182: Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells
Couverture rigide
ISBN 10 : 9401788189 ISBN 13 : 9789401788182
Editeur : Springer, 2014

Synopsis

Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson's disease and spinal cord injury. There will also be many applications in drug development. However, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications and increase the current low induction efficiency of their production.

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À propos de l'auteur

Xiaoyang Zhao obtained his Ph.D. from the Institute of Zoology, Chinese Academy of Science (CAS). He was supervised by Professor Qi Zhou, who is one of the most famous researchers in stem cells and regenerative medicine. During his Ph.D. study, Xiaoyang Zhao published 9 research articles as the first author in well-known international journals, such as Nature, Cell Research and the Journal of Biological Chemistry. He received the Excellent Graduates award from the Institute of Zoology, CAS and the first ISTT Young Investigator Award from the International Society for Transgenic Technologies (ISTT) in 2011. Dr. Xiaoyang Zhao is currently a principle investigator at the Institute of Zoology, CAS.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Springer
Date d'édition
2014
Langue
anglais
ISBN 10 
9401788189
ISBN 13 
9789401788182
Reliure
Relié
Nombre de pages
107
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Autres éditions populaires du même titre

9789402402261: Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells

Edition présentée

ISBN 10 :  9402402268 ISBN 13 :  9789402402261
Editeur : Springer, 2016
Couverture souple