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Synopsis
In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.
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À propos de l'auteur
Wenfei Jin obtained his Ph.D. from Shanghai Institute of Biological Sciences (SIBS), Chinese Academy of Sciences (CAS). He was supervised by Prof. Li Jin from Fudan University and Prof. Shuhua Xu from SIBS. During his Ph.D. study, Wenfei Jin published 11 research articles, of which 6 articles are as first or co-first author. He received SIBS-Eli Lilly Outstanding Ph.D. Thesis Awards from Eli Lilly, China, in 2012, and won the Excellent Doctoral Dissertation of CAS in 2013. Dr. Wenfei Jin is now a visiting fellow at NHLBI, National Institute of Health in the USA.
Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.
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Jin:Admixture Dynamics, Natural Selecti (eng)
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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations
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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations
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Springer Netherlands Aug 2016, 2016
ISBN 10 : 9402404309
ISBN 13 : 9789402404302
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications. 136 pp. Englisch. N° de réf. du vendeur 9789402404302
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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (Springer Theses)
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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations
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ISBN 10 : 9402404309
ISBN 13 : 9789402404302
Neuf
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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications. N° de réf. du vendeur 9789402404302
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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations
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Taschenbuch. Etat : Neu. Admixture Dynamics, Natural Selection and Diseases in Admixed Populations | Wenfei Jin | Taschenbuch | Springer Theses | xix | Englisch | 2016 | Springer | EAN 9789402404302 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. N° de réf. du vendeur 109582067
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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations
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Springer, Springer Aug 2016, 2016
ISBN 10 : 9402404309
ISBN 13 : 9789402404302
Neuf
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 136 pp. Englisch. N° de réf. du vendeur 9789402404302
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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (Springer Theses)
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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (Springer Theses)
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