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Advancing Development of Synthetic Gene Regulators: With the Power of High-throughput Sequencing in Chemical Biology - Couverture rigide
Synopsis
Nominated by Kyoto University as an outstanding Ph.D. thesis
Reviews multitasking applications of next-generation sequencing (NGS) technologies for chemical biologists
Describes low-cost Bind-n-Seq and small molecules based genomic pull-down development, identification of high-affinity binding sites for PIP conjugates using high-throughput sequencing, and the binding motif-guided redesign of PIPs
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Chandran:Advancing Development of Synth (eng)
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Advancing Development of Synthetic Gene Regulators
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Advancing Development of Synthetic Gene Regulators: With the Power of High-Throughput Sequencing in Chemical Biology
Edité par
SPRINGER NATURE Sep 2017, 2017
ISBN 10 : 9811065462
ISBN 13 : 9789811065460
Neuf
Couverture rigide
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence. 114 pp. Englisch. N° de réf. du vendeur 9789811065460
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Advancing Development of Synthetic Gene Regulators: With the Power of High-Throughput Sequencing in Chemical Biology (Springer Theses)
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Advancing Development of Synthetic Gene Regulators
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Springer Singapore, 2017
ISBN 10 : 9811065462
ISBN 13 : 9789811065460
Neuf
Couverture rigide
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Advancing Development of Synthetic Gene Regulators: With the Power of High-throughput Sequencing in Chemical Biology
Vendeur : Revaluation Books, Exeter, Royaume-Uni
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Hardcover. Etat : Brand New. 129 pages. 9.25x6.10x0.59 inches. In Stock. N° de réf. du vendeur x-9811065462
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Advancing Development of Synthetic Gene Regulators : With the Power of High-Throughput Sequencing in Chemical Biology
Edité par
Springer Nature Singapore, 2017
ISBN 10 : 9811065462
ISBN 13 : 9789811065460
Neuf
Couverture rigide
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
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Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence. N° de réf. du vendeur 9789811065460
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