Molecular Dynamics Analyses of Prion Protein Structures: The Resistance to Prion Diseases Down Under - Couverture rigide

Zhang, Jiapu

9789811088148: Molecular Dynamics Analyses of Prion Protein Structures: The Resistance to Prion Diseases Down Under

Couverture rigide

ISBN 10 : 9811088144 ISBN 13 : 9789811088148

Editeur : Springer Verlag, Singapore, 2018

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Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational" diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrP^C) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.

Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Str�ussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.

Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied.

This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

Les informations fournies dans la section � Synopsis � peuvent faire r�f�rence � une autre �dition de ce titre.

�diteur: Springer Verlag, Singapore
Date d'�dition: 2018
Langue: anglais
ISBN 10: 9811088144
ISBN 13: 9789811088148
Reliure: Reli�
Nombre de pages: 404
Coordonn�es du fabricant: Springer Nature Customer Service Center GmbH
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Molecular Dynamics Analyses of Prion Protein Structures (eng)

Zhang, Jiapu

Edit� par Springer, 2018

ISBN 10 : 9811088144 ISBN 13 : 9789811088148

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Molecular Dynamics Analyses of Prion Protein Structures

Jiapu Zhang

Edit� par Springer Nature Singapore Aug 2018, 2018

ISBN 10 : 9811088144 ISBN 13 : 9789811088148

Neuf Couverture rigide

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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called 'protein structural conformational' diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the beta2- 2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Str�ussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-beta structure PrP peptides are well studied. This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students. 408 pp. Englisch. N� de r�f. du vendeur 9789811088148

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Molecular Dynamics Analyses of Prion Protein Structures

Jiapu Zhang

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Gebunden. Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Systemically studies all the structures of PrPs and associations&nbsp &nbsp Introduces the reproducible Molecular Dynamics, QM/MM, Optimization skills into the studiesThe 1011 color photos lead you are fast and reliable to know. N� de r�f. du vendeur 209559389

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Molecular Dynamics Analyses of Prion Protein Structures : The Resistance to Prion Diseases Down Under

Jiapu Zhang

Edit� par Springer, 2018

ISBN 10 : 9811088144 ISBN 13 : 9789811088148

Neuf Couverture rigide

Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called 'protein structural conformational' diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the beta2- 2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Str�ussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-beta structure PrP peptides are well studied. This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students. N� de r�f. du vendeur 9789811088148

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Molecular Dynamics Analyses of Prion Protein Structures

Jiapu Zhang

Edit� par Springer Nature Singapore, Springer Nature Singapore Aug 2018, 2018

ISBN 10 : 9811088144 ISBN 13 : 9789811088148

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Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called 'protein structural conformational� diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the �2-�2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Str�ussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-� structure PrP peptides are well studied.This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 408 pp. Englisch. N� de r�f. du vendeur 9789811088148

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