Nmr With Biological Macromolecules In Solution: A Selection Of Papers Published From 1996 To 2020 By Kurt Wuthrich - Couverture souple

Couverture souple

ISBN 10 : 9811239134 ISBN 13 : 9789811239137

Editeur : WSPC, 2021

Synopsis

The book provides insights into the research of the Kurt Wüthrich laboratories from 1996–2020. During this time period, the technique of nuclear magnetic resonance (NMR) spectroscopy in solution went through several breakthroughs, while maturing into a standard method of structural biology. With the introduction of TROSY (transverse relaxation-optimized spectroscopy), the range of accessible molecular sizes was extended about thirty-fold, and efficient protein structure determination resulted from the demands of the structural genomics initiative. Applications in fundamental biology and biomedicine include studies of prion proteins and prion diseases (TSEs), the SARS-Corona virus proteome, trans-membrane signalling by G protein-coupled receptors (GPCRs), and signal transfer by pheromones. Key publications from the Kurt Wüthrich laboratories are placed in perspective, providing insights into new aspects of NMR spectroscopy in structural biology. In addition to methods development, this includes applications in diverse areas of biological research, such as prion proteins and their role in transmissible spongiform encephalopathies (TSEs), trans-membrane signal transfer by G protein-coupled receptors (GPCRs), structural characterization of the SARS-Corona virus proteome , metabolic-flux profiling in bacterial cultures, and signal transfers by pheromones.

A propos du livre

À propos de l'auteur

<p><strong>Kurt Wüthrich</strong> is the Cecil H and Ida M Green Professor of Structural Biology at Scripps Research, La Jolla, CA, USA, Professor of Biophysics at the ETH Zürich, Zürich, Switzerland, and Distinguished Senior Professor at the iHuman Institute, ShanghaiTech University, Shanghai, China. For 50 years, Wüthrich groups at the ETH Zürich, at Scripps Research and at the iHuman Institute have used nuclear magnetic resonance spectroscopy (NMR) for research in structural biology. Contributions include the method of protein structure determination with NMR in solution, and the use of the principles of transverse relaxation-optimized spectroscopy (TROSY) for NMR experiments with large supramolecular assemblies. Applications over the years were focused on differentiation in higher organisms, immune suppression and neuropathology. As of April 2019, research using NMR techniques is continued at ShanghaiTech University, with a focus on transmembrane signal transfer by G protein-coupled receptors (GPCRs). At Scripps Research and the ETH Zürich, projects on the general theme ""healthcare in the ageing human societies of the 21st century"" are pursued, mainly considering the impact of sarcopenia on the human healthspan. Kurt Wüthrich's achievements have been recognized by the Prix Louis Jeantet de Médecine, the Kyoto Prize in Advanced Technology, the Nobel Prize in Chemistry, and by a number of other awards and honorary degrees.</p>

Détails de l'édition

• Éditeur: WSPC
• Date d'édition: 2021
• Langue: anglais
• ISBN 10: 9811239134
• ISBN 13: 9789811239137
• Reliure: Broché
• Nombre de pages: 264
• Éditeur: Wuthrich Kurt
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible