Advancing Development of Synthetic Gene Regulators: With the Power of High-Throughput Sequencing in Chemical Biology - Couverture souple

Chandran, Anandhakumar

9789811348990: Advancing Development of Synthetic Gene Regulators: With the Power of High-Throughput Sequencing in Chemical Biology

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ISBN 10 : 9811348995 ISBN 13 : 9789811348990

Editeur : Springer, 2019

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Nominated by Kyoto University as an outstanding Ph.D. thesis
Reviews multitasking applications of next-generation sequencing (NGS) technologies for chemical biologists
Describes low-cost Bind-n-Seq and small molecules based genomic pull-down development, identification of high-affinity binding sites for PIP conjugates using high-throughput sequencing, and the binding motif-guided redesign of PIPs

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�diteur: Springer
Date d'�dition: 2019
Langue: anglais
ISBN 10: 9811348995
ISBN 13: 9789811348990
Reliure: Broch�
Nombre de pages: 132
Coordonn�es du fabricant: non disponible
Personne responsable: CMN Printpool Inh. Mathis Neumann
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ISBN 10 : 9811065462 ISBN 13 : 9789811065460
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Advancing Development of Synthetic Gene Regulators. With the Power of High-Throughput Sequencing in Chemical Biology.

Chandran, Anandhakumar

Edit� par Singapore, Springer., 2018

ISBN 10 : 9811348995 ISBN 13 : 9789811348990

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XV, 114 p. Softcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband besto�en, daher M�ngelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Springer Theses. Recognizing Outstanding Ph.D. Research. Sprache: Englisch. N� de r�f. du vendeur 35216AB

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Advancing Development of Synthetic Gene Regulators: With the Power of High-Throughput Sequencing in Chemical Biology (Springer Theses)

Chandran, Anandhakumar

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ISBN 10 : 9811348995 ISBN 13 : 9789811348990

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Advancing Development of Synthetic Gene Regulators: With the Power of High-Throughput Sequencing in Chemical Biology (Springer Theses)

Chandran, Anandhakumar

Edit� par Springer, 2019

ISBN 10 : 9811348995 ISBN 13 : 9789811348990

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Advancing Development of Synthetic Gene Regulators: With the Power of High-Throughput Sequencing in Chemical Biology (Springer Theses)

Chandran, Anandhakumar

Edit� par Springer, 2019

ISBN 10 : 9811348995 ISBN 13 : 9789811348990

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Advancing Development of Synthetic Gene Regulators

Anandhakumar Chandran

Edit� par Springer Nature Singapore Jan 2019, 2019

ISBN 10 : 9811348995 ISBN 13 : 9789811348990

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book focuses on an 'outside the box' notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)-N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence. 132 pp. Englisch. N� de r�f. du vendeur 9789811348990

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