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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products - Couverture souple
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Nominated as an outstanding Ph.D. thesis by Kyoto University
Describes a pioneering chemistry-based screening process for drug discovery
Provides valuable insights for the field of organic chemistry, especially regarding the total synthesis of natural products and proteins
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Noguchi:Development of Chemistry-Based (eng)
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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products
Edité par
Springer Nature Singapore Dez 2018, 2018
ISBN 10 : 9811349177
ISBN 13 : 9789811349171
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested only natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an -tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry. 96 pp. Englisch. N° de réf. du vendeur 9789811349171
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Development of Chemistry-based Screening Platform for Access to Mirror-image Library of Natural Products
Edité par
Springer, 2018
ISBN 10 : 9811349177
ISBN 13 : 9789811349171
Ancien ou d'occasion
Couverture souple
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Development of Chemistry-based Screening Platform for Access to Mirror-image Library of Natural Products
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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products
Edité par
Springer Singapore, 2018
ISBN 10 : 9811349177
ISBN 13 : 9789811349171
Neuf
Couverture souple
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror. N° de réf. du vendeur 449937694
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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products (Springer Theses)
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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested only natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an -tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry. N° de réf. du vendeur 9789811349171
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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products (Springer Theses)
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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products
Edité par
Springer, Springer Dez 2018, 2018
ISBN 10 : 9811349177
ISBN 13 : 9789811349171
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Nominated as an outstanding Ph.D. thesis by Kyoto UniversityDescribes a pioneering chemistry-based screening process for drug discoveryProvides valuable insights for the field of organic chemistry, especially regarding the total synthesis of natural products and proteinsSpringer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 96 pp. Englisch. N° de réf. du vendeur 9789811349171
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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products (Springer Theses)
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Paperback. Etat : Brand New. reprint edition. 96 pages. 9.25x6.10x0.28 inches. In Stock. N° de réf. du vendeur x-9811349177
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