Debating Cancer: The Paradox in Cancer Research - Couverture rigide

Heng, Henry H Q

Couverture rigide

ISBN 10 : 9814520845 ISBN 13 : 9789814520843

Editeur : World Scientific Publishing Co Pte Ltd, 2015

Synopsis

Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology.

This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research.

A propos du livre

Présentation de l'éditeur

Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology.

This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research.

Revue de presse

By critically analyzing the currently available data, the author compared gene- and genome-based theories. This book will serve as an excellent resource for cancer researchers. --Journal of Korean Medical Science

This is a very worthwhile book, one that opens a new and important perspective on the causes of cancer, which the field as a whole needs to consider carefully. The old paradigm is, at the very least, incomplete and insufficient. The ideas presented here, in contrast, may help the field ultimately fashion a better and more useful one, which, in turn, might lead to improved therapies. --BioEssays

The author focuses clearly on what he wants to achieve with this book: create discussions on how to continue cancer research best, and to find better theories than gene mutation theory to make tumors accessible and curable in the end. This book should be read by each one working in cancer research, diagnostics and treatment, including students of medicine, biology and bioinformatics. --European Journal of Human Genetics

Détails de l'édition

• Éditeur: World Scientific Publishing Co Pte Ltd
• Date d'édition: 2015
• Langue: anglais
• ISBN 10: 9814520845
• ISBN 13: 9789814520843
• Reliure: Relié
• Numéro d'édition: 1
• Nombre de pages: 464
• Coordonnées du fabricant: non disponible
• Personne responsable: gpsr@libri.de; gpsr@libri.de; ; Friedensallee 273; Hamburg; 22763; Allemagne